细胞自噬与凋亡相互作用分子机制的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (9): 1342-1346.

细胞自噬与凋亡相互作用分子机制的研究进展

张杨¹, 孙弯弯², 陆丽丹³, 冯晓玲^1*

1.黑龙江中医药大学附属第一医院妇科, 黑龙江哈尔滨 150036;
2.黑龙江中医药大学, 黑龙江哈尔滨 150040;
3.南京中医药大学常熟附属医院, 江苏常熟 215500

收稿日期:2020-06-08 修回日期:2020-10-15 出版日期:2021-09-05 发布日期:2021-09-02
通讯作者: *doctorfxl@163.com
基金资助:
中国博士后科学基金(2019M661320);国家自然科学基金(81973894);

Research progress on molecular mechanism of the interaction between autophagy and apoptosis

ZHANG Yang¹, SUN Wan-wan², LU Li-dan³, FENG Xiao-ling^1*

1. Department of Gynecology, the First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150036;
2. Heilongjiang University of Chinese Medicine, Harbin 150040;
3. Changshu Hospital Affiliated to Nanjing University of Chinese Medicine,Changshu 215500,China

Received:2020-06-08 Revised:2020-10-15 Online:2021-09-05 Published:2021-09-02
Contact: *doctorfxl@163.com

摘要/Abstract

摘要： 细胞自噬与细胞凋亡是两个不同的生理现象,但其在功能上有着密切的联系。本文主要介绍细胞自噬和凋亡的分类及发生过程,并就自噬体形成过程中的一些关键调节蛋白以及凋亡和抗凋亡蛋白的双重作用对自噬和凋亡的影响进行论述,从而探讨细胞自噬与凋亡之间的关系,以期为进一步研究自噬与凋亡相关疾病提供理论基础。

关键词: 分子机制, 自噬相关基因(Atg), caspase

Abstract: Autophagy and apoptosis are two different physiological phenomena, however they are closely related in function. This paper introduces the classification and process of autophagy and apoptosis, and discusses the effects of some key regulatory proteins in the formation of autophagosome and the dual role of apoptosis and anti-apoptosis proteins on autophagy and apoptosis, so as to explore the relationship between autophagy and apoptosis, and to provide theoretical basis for further study of autophagy and apoptosis related diseases.

Key words: molecular mechanism, autophagy-related gene(Atg), caspase

中图分类号:

R329

张杨, 孙弯弯, 陆丽丹, 冯晓玲. 细胞自噬与凋亡相互作用分子机制的研究进展[J]. 基础医学与临床, 2021, 41(9): 1342-1346.

ZHANG Yang, SUN Wan-wan, LU Li-dan, FENG Xiao-ling. Research progress on molecular mechanism of the interaction between autophagy and apoptosis[J]. Basic & Clinical Medicine, 2021, 41(9): 1342-1346.

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