基础医学与临床 ›› 2021, Vol. 41 ›› Issue (6): 904-908.

• 短篇综述 • 上一篇    下一篇

抑制侵袭性真菌的新型分子及其作用靶点研究进展

郭希1, 赖莘秀1, 杨媚滟1, 李峤桢1, 王思行1, 宋章永1,2*   

  1. 西南医科大学 1.基础医学院 病原微生物教研室; 2.公共实验技术中心分子生物学技术平台, 四川 泸州 646000
  • 收稿日期:2020-05-04 修回日期:2020-08-24 出版日期:2021-06-05 发布日期:2021-05-31
  • 通讯作者: *szy83529@163.com
  • 基金资助:
    四川省科技厅项目(2019YJ0407);泸州市科技局项目(2018-JYJ-32, 2019-RCM-94);大学生创新创业训练项目(S201910738107)

Research progress on novel molecules and new targets for the control of invasive fungi

GUO Xi1, LAI Xin-xiu1, YANG Mei-yan1, LI Qiao-zhen1, WANG Si-hang1, SONG Zhang-yong1,2*   

  1. 1. Department of Pathogenic Biology, School of Basic Medical Sciences; 2. Molecular Biotechnology Platform, Public Center of Experimental Technology, South-west Medical University, Luzhou 646000, China
  • Received:2020-05-04 Revised:2020-08-24 Online:2021-06-05 Published:2021-05-31
  • Contact: *szy83529@163.com

摘要: 目前药物治疗侵袭性真菌感染受其严重的毒副作用及耐药性菌株等挑战,故研发安全、高效的新型抗真菌药物对于解决现状具有重要意义。本文从侵袭性真菌作用靶点着手,在小分子物质和次生代谢产物等方面挖掘涉及真菌生物膜、细胞壁、关键代谢酶及线粒体等作用靶点及其机制,以期为防治侵袭性真菌的新药研发提供借鉴。

关键词: 侵袭性真菌, 靶点, 小分子抑制剂, 分子机制

Abstract: At present, the drug treatment for invasive fungal infection is challenged by serious adverse effects and drug resistance. Therefore, the research and development of safe and effective new antifungal drugs is a great importance to support the clinical treatment of invasive fungal diseases. This article reviewed new targets of invasive fungi, and explores the underlying mechanisms of fungal biofilm formation, cell wall,key metabolic enzymes, mitochondria in the aspects of small molecule inhibitors and secondary metabolites, which may provide reference for the research and development of new drugs.

Key words: invasive fungi, target, small molecule inhibitors, molecular mechanism

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