硫化氢通过抑制氧化应激减轻糖尿病心肌病病变

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (5): 739-743.

硫化氢通过抑制氧化应激减轻糖尿病心肌病病变

矫立杰, 魏亚新, 李鸿珠^*

哈尔滨医科大学基础医学院病理生理学教研室, 黑龙江哈尔滨 150086

收稿日期:2020-05-09 修回日期:2020-07-29 出版日期:2021-05-05 发布日期:2021-05-06
通讯作者: ^*hongzhuli61@163.com
基金资助:
国家自然科学基金(81770486); 黑龙江省自然科学基金(LH2020H012);哈尔滨医科大学研究生科研创新项目(YJSKYCX2019-68HYD)

Hydrogen sulfide attenuates diabetic cardiomyopathy by inhibiting oxidative stress

JIAO Li-jie, WEI Ya-xin, LI Hong-zhu^*

Department of Pathophysiology,School of Basic Medicine, Harbin Medical University, Harbin 150086, China

Received:2020-05-09 Revised:2020-07-29 Online:2021-05-05 Published:2021-05-06
Contact: ^*hongzhuli61@163.com

摘要/Abstract

摘要： 尽管糖尿病心肌病(DCM)的病理机制众多,但氧化应激是DCM发病重要的原因之一。了解氧化应激在DCM中的发生发展对于DCM新的靶向治疗至关重要。硫化氢(H₂S)对治疗各种心血管疾病发挥着重要的作用。尤其是H₂S通过调控多种途径抑制氧化应激可减轻DCM的发生。

关键词: 硫化氢(H₂S), 活性氧, 糖尿病心肌病, 蛋白酶途径, 非蛋白酶途径

Abstract: Although there are a variety of pathological mechanisms attributed to diabetic cardiomyopathy (DCM), oxidative stress is one of the most important causes of DCM. Understanding the occurrence and development of oxidative stress in DCM is very important for the new targeted therapy of DCM. In addition, hydrogen sulfide (H₂S) plays an important role in the treatment of various cardiovascular diseases. In particular, H₂S can reduce DCM by inhibiting oxidative stress through various pathways.

Key words: hydrogen sulfide (H₂S), reactive oxygen species, diabetic cardiomyopathy, protease pathway, non-protease pathway

中图分类号:

R310.4430

矫立杰, 魏亚新, 李鸿珠. 硫化氢通过抑制氧化应激减轻糖尿病心肌病病变[J]. 基础医学与临床, 2021, 41(5): 739-743.

JIAO Li-jie, WEI Ya-xin, LI Hong-zhu. Hydrogen sulfide attenuates diabetic cardiomyopathy by inhibiting oxidative stress[J]. Basic & Clinical Medicine, 2021, 41(5): 739-743.

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