基础医学与临床 ›› 2021, Vol. 41 ›› Issue (3): 442-447.

• 短篇综述 • 上一篇    下一篇

铁死亡调控机制及在肺癌治疗中的研究进展

徐飞,陈维达,郭溟浩,陈泽涛   

  1. 山东中医药大学附属医院
  • 收稿日期:2020-03-29 修回日期:2020-06-29 出版日期:2021-03-05 发布日期:2021-03-01
  • 通讯作者: 陈泽涛 E-mail:zetaochen2007@126.com
  • 基金资助:
    山东中医药大学附属医院高层次引进人才项目

Progress of ferroptosis mechanism and application in lung cancer therapy

  • Received:2020-03-29 Revised:2020-06-29 Online:2021-03-05 Published:2021-03-01

摘要: 铁死亡是一种铁依赖性的脂质过氧化、活性氧自由基大量累积所致的细胞死亡模式,在形态和生化水平上都不同于细胞凋亡、坏死和自噬。它在肺癌发生发展中发挥重要作用,诱导肺癌细胞铁死亡成为抗肺癌治疗的新策略。本文对铁死亡发生过程中铁代谢、氨基酸和谷胱甘肽代谢、脂质代谢的主要调节机制和在肺癌发生发展、化疗药物耐药、放疗抵抗与免疫治疗中的作用分别进行阐述,以期加深对铁死亡的认识,为肺癌的临床治疗提供新方向和新思路。

关键词: 细胞程序性死亡, 铁死亡, 生化过程, 肺肿瘤, 肺癌治疗

Abstract: Ferroptosis is a newly discovered cell death form characterized by accumulation of iron dependent lipid peroxidation and reactive oxygen species, which is different from apoptosis, necrosis and autophagy in morphology and biochemical. It is involved in the occurrence and development of lung cancer, and inducing ferroptosis seems to become a new strategy for anti-lung cancer. This review includes the followings: mechanism of ferroptosis from the aspects of iron metabolism, amino acid and glutathione metabolism and lipid metabolism; its effects on lung cancer occurrence and progression, chemotherapy resistance, radiation resistance and immunotherapy respectively, as to advance our understanding of ferroptosis and provides a new direction and new idea for lung cancer therapy.

Key words: programmed cell death, ferroptosis, biochemical process, lung cancer, therapy