基础医学与临床 ›› 2021, Vol. 41 ›› Issue (3): 415-418.

• 临床研究 • 上一篇    下一篇

银屑病患者外周血淋巴细胞亚群的变化

刘燕敏1,赵新程1,李俊琴1,张开明2   

  1. 1. 山西医科大学太原中心医院皮肤科研究所山西省免疫皮肤病干细胞重点实验室,
    2. 山西省太原市中心医院
  • 收稿日期:2020-04-15 修回日期:2020-08-21 出版日期:2021-03-05 发布日期:2021-03-01
  • 通讯作者: 张开明 E-mail:zhangkaiming@sina.com
  • 基金资助:
    单卵双胞胎银屑病患者denovo突变的细胞模型验证及T细胞功能/表观遗传学研究

Changes of peripheral blood lymphocyte subsets in patients with psoriasis

  • Received:2020-04-15 Revised:2020-08-21 Online:2021-03-05 Published:2021-03-01

摘要: 目的 探讨进行期、静止期和退行期的银屑病患者外周血淋巴细胞亚型的变化及免疫机制。方法 本研究评估了77例寻常型银屑病患者(28例进行期,23例静止期,26例退行期)的外周血单个核细胞(PBMC)各组中各淋巴细胞的比率。结果 与退行期相比,进行期和静止期患者的CD3+、CD4+和CD8+淋巴细胞的百分率均显著升高(p<0.01)。同进行期比较,静止期和退行期的CD4-CD8-淋巴细胞的百分率降低(p<0.05)。CD3-CD16+CD56+比例随病情稳定而增高,CD45+CD14+比例逐渐下降和CD3-CD19+与病情呈负相关,3组的差异明显(p<0.05)。结论 进行期、静止期和退行期3组银屑病患者的淋巴细胞亚群存在显著的差异,进一步支持银屑病的免疫发病机制。

关键词: 银屑病, T淋巴细胞, 白细胞, B淋巴细胞

Abstract: Objective To investigate the changes and immune mechanisms of peripheral blood lymphocyte subtypes in psoriasis patients with progressive, stationary and regression stages. Methods The percentage of lymphocytes in each group of peripheral blood mononuclear cells (PBMC) in 77 patients with psoriasis vulgaris including 28 patients during progression, 23 patients during stationary, and 26 patients during regression). Results The percentages of CD3+, CD4+ and CD8+ lymphocytes were significantly increased in both the progression and stationary stages compared with the regression stage (p<0.01). CD4-CD8- in the peripheral blood lymphocyte subsets of the patients showed a decreasing trend according to progression, stationary and regression stages (p<0.05). The result showed that the proportion of CD3-CD16+CD56+ increased with the stability of the disease, the proportion of CD45+CD14+ gradually decreased, and the proportion of CD3-CD19+ was negatively correlated with the disease (p<0.05). Conclusions there were significant differences in lymphocyte subsets in the three groups of patients with psoriasis, which further supported the immune pathogenesis of psoriasis.

Key words: Psoriasis, T lymphocytes, White blood cells, B lymphocyte

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