基础医学与临床 ›› 2021, Vol. 41 ›› Issue (3): 388-392.

• 研究论文 • 上一篇    下一篇

传统检测汗液氯离子方法对中国囊性纤维化患者的诊断价值

陈珂琪1,李雪1,徐文帅1,高君1,夏良裕2,徐凯峰1,田欣伦3   

  1. 1. 中国医学科学院北京协和医院
    2. 中国医学科学院 北京协和医学院 北京协和医院
    3. 北京协和医院
  • 收稿日期:2020-03-06 修回日期:2020-07-27 出版日期:2021-03-05 发布日期:2021-03-01
  • 通讯作者: 田欣伦 E-mail:tianxl@pumch.cn
  • 基金资助:
    中国医学科学院医学与健康科技创新工程项目;国家十三五规划罕见病临床队列研究项目

Diagnostic value of traditional sweat chloride test for Chinese cystic fibrosis patients

  • Received:2020-03-06 Revised:2020-07-27 Online:2021-03-05 Published:2021-03-01
  • Contact: Xin-Lun TIAN E-mail:tianxl@pumch.cn

摘要: 目的 探讨传统检测汗液氯离子方法的准确性及对中国囊性纤维化(CF)患者的诊断价值。方法 用传统检测氯离子方法测定了2012年1月至今2019年10月北京协和医院118例疑似CF患者的汗液氯离子浓度,并与患者的最终诊断比较并分析。结果 筛查患者数118例,平均年龄(25.8±13.6)岁。其中102例获得有效汗液氯离子检测数据,其浓度中位数43.3 mmol/L(IQR 23.8~120.1 mmol/L)。80例患者的汗液氯离子检测结果符合诊断;39例汗液氯离子检测为阳性结果(≥60 mmol/L),其中31例(79.49%)确诊CF;40例阴性结果(<30 mmol/L),其中32例(80%)排除CF;23例处于临界值(30~59 mmol/L),其中17例(73.91%)排除CF,其余6例(26.09%)未能明确诊断; 66例(64.71%)具有可重复性。结论 北京协和医院氯离子测定结果的CF阳性预测值为79.49%,阴性预测值为80%。传统氯离子检测方法对于中国CF患者具有较高诊断价值。

关键词: 囊性纤维化(CF), 汗液氯离子检测, 阳性预测值

Abstract: Objective To explore the accuracy of the method of the traditional sweat chloride test and its diagnostic value for Chinese patients with cystic fibrosis (CF). Methods The sweat chloride level in 118 patients who were suspected to have CF in Peking Union Medical College Hospital from Jan 2012 to Oct 2019 were measured,and the results were compared with the final diagnosis of these patients. Results The patients’ age were 25.8±13.6 years old (15 months-67 years old). 102 out of 118 patients obtained valid chloride level from their sweat chloride tests with median concentration of 43.3 mmol/L (inter-quartile range: 23.8-120.1 mmol/L). 80 were consistent with their diagnosis. 39 patients had sweat chloride values higher than 60 mmol/L, while 31 (79.49%) of them were confirmed CF diagnosis. 40 cases of sweat chloride level lower than 30 mmol/L, of which 32 (80%) cases were excluded from CF. 23 patients had sweat chloride level between 30 and 59 mmol/L, while 17 (73.91%) of them were excluded from CF diagnosis. 66 (64.71%) of our patients had reproducible results of the sweat chloride level. Conclusions The positive predictive value of the sweat chloride test is 79.49% and the negative predictive value was 80% using traditional sweat chloride test measurement. The traditional sweat chloride test has high diagnostic value for Chinese CF patients.

Key words: cystic fibrosis (CF), the traditional sweat chloride test, positive predictive value

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