斑马鱼在急性肾损伤研究中的应用进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (2): 257-261.

斑马鱼在急性肾损伤研究中的应用进展

马田田^1,2, 施潇潇^1,2, 陈丽萌^1,2*

中国医学科学院北京协和医学院北京协和医院 1.肾内科; 2.疑难重症及罕见病国家重点实验室, 北京 100730

收稿日期:2020-03-21 修回日期:2020-05-07 出版日期:2021-02-05 发布日期:2021-01-19
通讯作者: ^*chenlimeng@pumch.cn
基金资助:
国家自然科学基金(81970607,81470937);宁夏重点研发计划-重大重点项目(东西部合作项目)(2018BFG02010);首都卫生发展科研专项(CFH 2020-2-4018);北京市自然科学基金-海淀原始创新联合基金资助(L202035);中国医学科学院医学与健康科技创新工程项目(CIFMS 2020-I2M-C&T-A-001);北京市科技重大专项首都临床特色应用研究与成果推广(Z171100001017196);中国医学科学院医学与健康科技创新工程项目(CIFMS 2016-I2M-2-004);国家重点研发计划“精准医学研究”项目(2016YFC0901500)

Advances in the application of zebrafish in the study of acute kidney injury

MA Tian-tian^1,2, SHI Xiao-xiao^1,2, CHEN Li-meng^1,2*

1. Department of Nephrology, 2. State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730, China

Received:2020-03-21 Revised:2020-05-07 Online:2021-02-05 Published:2021-01-19
Contact: ^*chenlimeng@pumch.cn

摘要/Abstract

摘要： 急性肾损伤(AKI)是临床常见的危急重症,以肾功能的突发持续下降为特征。斑马鱼作为一种脊椎动物模式生物,在肾形态、生理和功能方面与人高度相似,是理想的研究肾脏疾病的动物模型,弥补了哺乳动物模型的不足。本文将简述斑马鱼肾脏的结构和功能、在AKI研究中的建模方法以及斑马鱼模型应用于AKI研究的优势。

关键词: 斑马鱼, 肾脏疾病, 急性肾损伤, 肾脏再生

Abstract: Acute kidney injury (AKI) is a common critical illness in clinic, characterized by a sudden and continuous decline in kidney function. zebrafish, as a vertebrate model organism, is highly similar to human being in terms of kidney morphology, physiology and function, and is an ideal animal model for the study of kidney disease, which makes up for the deficiency of mammalian model. This review briefly described the structure and function of zebrafish kidney, the modeling methods and its application in AKI research.

Key words: zebrafish, kidney disease, acute kidney injury, kidney regeneration

中图分类号:

R332

马田田, 施潇潇, 陈丽萌. 斑马鱼在急性肾损伤研究中的应用进展[J]. 基础医学与临床, 2021, 41(2): 257-261.

MA Tian-tian, SHI Xiao-xiao, CHEN Li-meng. Advances in the application of zebrafish in the study of acute kidney injury[J]. Basic & Clinical Medicine, 2021, 41(2): 257-261.

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