线粒体转运系统和降解系统的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (10): 1523-1528.

线粒体转运系统和降解系统的研究进展

王梦伊, 李倩竹, 张世武, 舒凤, 张伟华^*

哈尔滨医科大学病理生理学教研室, 黑龙江哈尔滨 150080

收稿日期:2020-07-08 修回日期:2020-11-17 发布日期:2021-09-29
通讯作者: *zhangwh116@126.com
基金资助:
国家自然科学基金(81970317)

Research progress on the mitochondrial translocation and degradation

WANG Meng-yi, LI Qian-zhu, ZHANG Shi-wu, SHU Feng, ZHANG Wei-hua^*

Department of Pathophysiology, Harbin Medical University, Harbin 150080, China

Received:2020-07-08 Revised:2020-11-17 Published:2021-09-29
Contact: *zhangwh116@126.com

摘要/Abstract

摘要： 线粒体蛋白稳态的维持需要线粒体转运系统和降解系统协同调控,其功能障碍是代谢疾病的病因之一。转运系统障碍使核编码的线粒体蛋白无法进入线粒体,降解系统障碍则使细胞无法及时清除异常蛋白,最终导致线粒体损伤。在糖尿病患者的心肌细胞线粒体中,转运系统和降解系统失调引起的电子传递链(ETC)活性降低、活性氧(ROS)生成增加和产能减少是糖尿病心肌病(DCM)发生发展的主要原因。

关键词: 线粒体蛋白转运, 线粒体降解, 糖尿病心肌病

Abstract: The mitochondrial proteins translocation and degradation coordinate to maintain the proteostasis network of mitochondria. Their dysfunction is one of the pathogenesis mechanims of metabolic diseases. The dysfunction of transportation and degradation prevents the nuclear-encoded mitochondrial protein from importing and cells from clearing abnormal proteins in time, which ultimately leads to mitochondrial damage. In the diabetic cardiomyocyte, decreased activity of electron transport chain (ETC), increased production of reactive oxygen species (ROS) and decreased energy productivity caused by disorders of mitochondrial transportation and degradation are main reasons for the development of diabetic cardiomyopathy (DCM).

Key words: mitochondrial translocation, mitochondrial degradation, diabetic cardiomyopathy

中图分类号:

R363

王梦伊, 李倩竹, 张世武, 舒凤, 张伟华. 线粒体转运系统和降解系统的研究进展[J]. 基础医学与临床, 2021, 41(10): 1523-1528.

WANG Meng-yi, LI Qian-zhu, ZHANG Shi-wu, SHU Feng, ZHANG Wei-hua. Research progress on the mitochondrial translocation and degradation[J]. Basic & Clinical Medicine, 2021, 41(10): 1523-1528.

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