肠离子通道在肠易激综合征发病机制中的作用研究进展

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (8): 1135-1139.

肠离子通道在肠易激综合征发病机制中的作用研究进展

兰菲, 刘太阳, 杨杰^*

贵州医科大学附属医院消化内科, 贵州贵阳 550004

收稿日期:2019-11-12 修回日期:2020-03-26 出版日期:2020-08-05 发布日期:2020-07-29
通讯作者: ^*yangjielaila@163.com
基金资助:
贵阳市科技计划项目(筑科合同[2018]1-85)

Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome

LAN Fei, LIU Tai-yang, YANG Jie^*

Department of Gastroenterology, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China

Received:2019-11-12 Revised:2020-03-26 Online:2020-08-05 Published:2020-07-29
Contact: ^*yangjielaila@163.com

摘要/Abstract

摘要： 离子通道广泛存在于消化道黏膜中,其表达和(或)功能异常是肠易激综合征(IBS)重要的致病机制之一。电压门控钠离子通道(VGSCs)、电压门控钙离子通道(VGCCs)及瞬时受体电位通道(TRPs)等离子通道不同程度地参与IBS胃肠运动及内脏超敏,是调节胃肠运动和内脏超敏的关键病理生理机制及治疗靶点。

关键词: 肠易激综合征, 发病机制, 离子通道

Abstract: Ion channels are widely present in mucous membranes of the digestive tract, their abnormal expression and(or) function are important pathogenic mechanisms of irritable bowel syndrome (IBS). The plasma channels of voltage-gated sodium channels (VGSCs), voltage-gated calcium channels (VGCCs) and transient receptor potential channels (TRPs) are involved in IBS gastrointestinal motility and visceral hypersensitivity to varying degrees. They are key pathophysiological and therapeutic targets for regulating gastrointestinal motility and visceral hypersensitivity.

Key words: irritable bowel syndrome, pathogenesis, ion channels

中图分类号:

R574.4

兰菲, 刘太阳, 杨杰. 肠离子通道在肠易激综合征发病机制中的作用研究进展[J]. 基础医学与临床, 2020, 40(8): 1135-1139.

LAN Fei, LIU Tai-yang, YANG Jie. Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome[J]. Basic & Clinical Medicine, 2020, 40(8): 1135-1139.

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