减毒沙门氏菌在抗肿瘤治疗中的应用

基础医学与临床 ›› 2019, Vol. 39 ›› Issue (9): 1356-1360.

减毒沙门氏菌在抗肿瘤治疗中的应用

蒋如如¹,李欣¹,李洁²,³,哈小琴⁴

1. 甘肃中医药大学
2. 兰州大学
3. 中国人民解放军联勤保障部队第九四〇医院
4. 兰州军区兰州总医院

收稿日期:2018-09-11 修回日期:2018-12-26 出版日期:2019-09-05 发布日期:2019-09-06
通讯作者: 哈小琴 E-mail:haxiaoqin2013@163.com
基金资助:
江苏省科技重大专项

Bacteria-mediated cancer therapy by attenuated Salmonella

Received:2018-09-11 Revised:2018-12-26 Online:2019-09-05 Published:2019-09-06

摘要/Abstract

摘要： 目前用于肿瘤治疗的细菌已逐渐发展为肿瘤治疗的潜在策略，这主要是由于细菌菌株的发展保持了良好的抗肿瘤功效，同时也具有低毒的特性。细菌介导的肿瘤治疗依赖于兼性厌氧菌，这些厌氧菌可以在氧化良好或贫氧区域存活，可靶向肿瘤。其中，减毒沙门氏菌作为基因递送载体、抗肿瘤免疫激活剂和肿瘤细胞死亡诱导剂，可通过改善宿主免疫环境、降低吲哚胺2,3-双加氧酶（IDO）和基质金属蛋白酶9（MMP-9）的表达以及调节肿瘤细胞的自噬与凋亡发挥内在抗肿瘤活性。

关键词: 沙门氏菌，肿瘤，减毒菌株

Abstract: The use of bacteria for cancer therapy has been gradually recognized as a potential therapeutic strategy, which mainly due to the development of bacterial strains to maintain excellent anti-tumor activity and lower toxicity to host. Bacteria-mediated cancer therapy relies on facultative anaerobes that can survive in well or poorly oxygenated regions and further target tumor. Herein, Salmonella have mainly been applied as gene-delivery vectors, antitumor immune activators and tumor cell death inducers. It can ameliorate the host immune environment, reduce the expression of indoleamine-2, 3-dioxygenase(IDO) and matrix metalloproteinase 9(MMP-9) and regulate the autophagy and apoptosis of tumor cells to exert intrinsic anti-tumor activity.

Key words: salmonella, neoplasms, attenuated strains

蒋如如李欣李洁哈小琴. 减毒沙门氏菌在抗肿瘤治疗中的应用[J]. 基础医学与临床, 2019, 39(9): 1356-1360.