基础医学与临床 ›› 2019, Vol. 39 ›› Issue (4): 560-563.
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何明月,袁芳,刘映红
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摘要： 细胞焦亡是由Gasdermin蛋白介导的一种程序性炎性细胞死亡方式，分为依赖caspase-1的经典途径和依赖caspase-4/5/11的非经典途径。炎性小体的激活在此过程中扮演重要角色。细胞焦亡参与肾脏疾病、动脉粥样硬化、神经系统疾病、感染性疾病等的发生发展,并发挥重要作用。通过对细胞焦亡作用机制及相关疾病的研究，为临床疾病的防治提供新思路。
关键词: 细胞焦亡, 炎性小体, caspase-1/4/5/11, GSDMD
Abstract: Pyroptosis is a programmed inflammatory cell necrosis medicated by gasdermin protein, including caspase-1-mediated canonical pathway and caspase-4/5/11-mediated noncanonical pathway. Inflammasome activation plays an important role in this process. Pyroptosis plays an important role in the development and progression of renal diseases, atherosclerosis, nervous system diseases, infectious diseases, etc. The study on the mechanism of pyroptosis and related diseases provides new ideas for the prevention and treatment of clinical diseases.
Key words: pyroptosis, inflammasome, caspase-1/4/5/11, GSDMD
何明月 袁芳 刘映红. 细胞焦亡及相关疾病的研究进展[J]. 基础医学与临床, 2019, 39(4): 560-563.
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