基础医学与临床 ›› 2019, Vol. 39 ›› Issue (2): 260-263.
• 短篇综述 • 上一篇 下一篇
梅杰,朱一超
收稿日期:
修回日期:
出版日期:
发布日期:
通讯作者:
基金资助:
Received:
Revised:
Online:
Published:
Supported by:
摘要： 蛋白为形态发生紊乱关联激活因子l (Daam1)是形成素蛋白家族的成员，此蛋白含有1,068个氨基酸，并在人类各组织中广泛表达。Daam1在乳腺癌细胞中异常活化，与乳腺癌的转移、侵袭密切相关，鉴于其在乳腺癌转移过程中的重要作用，或可成为乳腺癌分子靶向治疗的新靶点。
关键词: 形态发生紊乱关联激活因子1, 乳腺癌, 转移, 信号转导
Abstract: Daam1(Dishevelled-associated activator of morphogenesis 1) is a member of the formin proteins, which contains 1,068 amino acids and is widely expressed in human tissues. Abnormal activation of Daam1 in breast cancer cells is closely associated with the metastasis and invasion of breast cancer. Given its important function in process of breast cancer metastasis, Daam1 may be the new molecular target for targeted therapy of breast cancer.
Key words: Daam1, Breast cancer, metastasis, signal transduction
中图分类号:
R737.9
梅杰 朱一超. 形成素蛋白Daam1与乳腺癌转移的研究进展[J]. 基础医学与临床, 2019, 39(2): 260-263.
0 / / 推荐
导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks
链接本文: http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2019/V39/I2/260
