基础医学与临床 ›› 2019, Vol. 39 ›› Issue (2): 252-255.
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张源洲,席雨鑫,温馨,李鸿珠
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摘要: 硫化氢(H2S)是近年来发现的第三个内源性气体信使分子,广泛分布于机体各个部位。H2S能减轻衰老缺血心肌细胞的缺血/再灌注(I/R)损伤和细胞凋亡,恢复缺血后适应(PC)对I/R损伤的保护作用。其作用机制主要与减轻氧化损伤、上调自噬和维持蛋白稳态有关。
关键词: 硫化氢, 衰老, 心肌缺血, 心肌细胞
Abstract: The hydrogen sulfide (H2S) is the third endogenous gas messenger in recent years and widely exists in the body. H2S reduces the ischemia/reperfusion (I/R) injury and apoptosis and restores the protective effect of ischemic post-conditioning on I/R injury in the aging ischemic cardiomyocytes. Its mechanism is mainly related to the reduction of oxidative damage, up-regulation of autophagy and maintenance of protein homeostasis.
张源洲 席雨鑫 温馨 李鸿珠. 硫化氢对衰老缺血心肌细胞保护作用的研究进展[J]. 基础医学与临床, 2019, 39(2): 252-255.
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