基础医学与临床 ›› 2018, Vol. 38 ›› Issue (2): 260-264.
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丁文斌1,戴佳敏1,张峰1,王学浩2,饶建华1
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摘要： 内质网应激(ERS)是一种重要的细胞自我保护机制，能够激活未折叠蛋白反应(UPR)，促进细胞的生存，但持续的ERS将导致细胞的凋亡。肝细胞内存在大量的内质网，许多肝脏相关疾病均与内质网应激有关，如酒精性肝病，非酒精性肝病，中毒性肝损伤，病毒性肝炎，肝恶性肿瘤及肝脏缺血再灌注损伤等。本文将从ERS在肝脏相关疾病发病机制中的作用以及在肝病干预治疗上的意义等方面进行综述。
关键词: 内质网应激, 未折叠蛋白反应, 细胞凋亡, 肝脏疾病
Abstract: Endoplasmic reticulum stress (ERS) is an important cellular self-protection mechanism. It can activate the unfolded protein response (UPR) that promotes cell survival, but sustained ERS will lead to cell apoptosis. There are a lot of endoplasmic reticulum in the liver cells, and many liver-related diseases are associated with endoplasmic reticulum stress, such as alcoholic liver disease, non-alcoholic liver disease, toxic liver injury, viral hepatitis, hepatic malignant tumors and hepatic ischemia-perfusion injury. This article will summarize the role of ERS in the pathogenesis of liver-related diseases and the significance of intervention in liver disease.
Key words: endoplasmic reticulum stress, unfolded protein response, apoptosis, liver disease
丁文斌 戴佳敏 张峰 王学浩 饶建华. 内质网应激在肝脏相关疾病中的研究进展[J]. 基础医学与临床, 2018, 38(2): 260-264.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2018/V38/I2/260
