基础医学与临床 ›› 2018, Vol. 38 ›› Issue (12): 1786-1790.
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黄铭江1,韩薇2
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摘要： 活性氧（ROS）的过量积聚及雷帕霉素靶点复合物1（mTORC1）的慢性激活可以加速衰老。Sestrins是一类高度保守的应激诱导蛋白，对于ROS和mTORC1通路的负调控起着重要作用，Sestrins通过何种机制来抑制上述通路目前尚不明确。近年，对于sestrin的一些重大发现极大的加深了对sestrin功能的理解，这些发现对于延缓衰老具有很大潜力。
关键词: 关键词：sestrins, 氧化应激, 雷帕霉素靶点, 衰老
Abstract: Previous studies have shown that excessive accumulation of reactive oxygen species(ROS) and chronic avtivation of mTORC1 will result in aging.Sestrins,a family of highly consevered stress-inducible proteins,are important negative regulators of both ROS and mTORC1 signaling pathways;however,the mechanistic basis of how sestrins suppress these pathways remains unknown.In recent years,great disvoveries about sestrins have deeply increased our understanding of sestrin function.These disvoveries have also uncovered new potential therapeutic strategies that may eventually enable us to attenuate aging and age-related diseases.
Key words: Key words：sestrins, oxidative stress , target of rapamycin, aging
黄铭江 韩薇. Sestrins延缓衰老作用的研究进展[J]. 基础医学与临床, 2018, 38(12): 1786-1790.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2018/V38/I12/1786
