基础医学与临床 ›› 2018, Vol. 38 ›› Issue (12): 1766-1770.
• 短篇综述 • 上一篇 下一篇
张力1,2,茆军2,张立1,黄正泉2,梅伟2,丁亮2,王培民2
收稿日期:
修回日期:
出版日期:
发布日期:
通讯作者:
基金资助:
Received:
Revised:
Online:
Published:
摘要： 细胞焦亡是一种特异性依赖caspace-1的新型细胞程序性死亡方式。相关刺激激活炎性小体并启动细胞焦亡，最终致使细胞死亡并释放促炎因子IL-1β、IL-18。细胞焦亡在多种纤维化疾病中介导形成“焦亡-炎性反应-纤维化”轴样病理改变，扩大炎性级联反应，加重组织纤维化病程进程。因此，细胞焦亡的启动逐渐成为药物靶点研究的新方向。
关键词: 细胞焦亡, 炎性小体, GSDMD, 组织纤维化
Abstract: Pyroptosis is a new type of programmed cell death that is specific to caspace-1. Associated stimuli activate inflammatory corpuscles and initiate pyroptosis, leading to cell death and the release of inflammatory factor IL-1β and IL-18. Pyroptosis mediates the axial pathological changes of "pyroptosis-inflammatory response-fibrosis" in many kinds of fibrosis diseases, expands inflammatory cascade reaction, and exacerbates the course of tissue fibrosis. Therefore, the initiation of cell pyroptosis has gradually become a new direction of drug target.
Key words: Pyroptosis, Inflammasome, GSDMD, Tissue fibrosis
中图分类号:
A
张力 茆军 张立 黄正泉 梅伟 丁亮 王培民. 细胞焦亡与组织纤维化[J]. 基础医学与临床, 2018, 38(12): 1766-1770.
0 / / 推荐
导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks
链接本文: http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2018/V38/I12/1766
