关键词: circRNA 动脉粥样硬化 心肌梗死 心肌纤维化

Abstract: Circular RNA (cirRNA) is a class of circlar of circular non-coding RNAs that exist in all organisms. With the development of sequencing technology, it has been found that there are thousands of circons in human being. At present, the most studied is that the circRNA can be a microRNA (miRNA) sponge, specifically absorbed miRNA, so that the expression of related miRNA in vivo is down-regulated. CircRNA has been found to play an important role in cardiovascular disease such as atherosclerosis, aortic aneurysm, myocardial infarction and coronary heart disease. CircRNA can regulate cardiac hypertrophy, myocardial fibrosis and cardiomyocyte apoptosis through different mechanisms, and then cause the corresponding development of cardiovascular disease.