非糜烂性反流病患者胃食管交界顺应性增加

基础医学与临床 ›› 2017, Vol. 37 ›› Issue (5): 714-717.

非糜烂性反流病患者胃食管交界顺应性增加

刘继喜¹,赵树巧²,刘芳¹,李晓讴¹,李靖涛¹

1. 中日友好医院
2. 石家庄第一医院

收稿日期:2016-11-01 修回日期:2016-12-23 出版日期:2017-05-05 发布日期:2017-04-19
通讯作者: 李靖涛 E-mail:lijingtao1106@126.com

Increased gastroesophageal junction compliance in patients with non-erosive reflux disease

Received:2016-11-01 Revised:2016-12-23 Online:2017-05-05 Published:2017-04-19

摘要/Abstract

摘要： 目的揭示非糜烂性反流病（NERD）的生物力学机制。方法纳入自2014年10月4日至2015年9月30日就诊于中日友好医院消化内科门诊符合NERD诊断的17例患者及健康志愿者17名。使用内镜联合EndoFlip技术对胃食管交界的横截面面积（CSA）、球囊内压力和顺应性（Δv/Δp）进行测定。结果随球囊容积增加，胃食管交界处的顺应性NERD组显著高于对照组（p<0.01）,而横截面积和球囊内压力变化不明显。结论非糜烂性反流病患者的胃食管交界的顺应性增加可能是其重要的发病机制之一。

关键词: 关键词：非糜烂性反流病, 顺应性, 胃食管交界

Abstract: Objective To explore the biomechanical mechanism of non-erosive reflux disease(NERD). Methods From October 4,2014 to September 30,2015，17 NERD patients and 17 healthy controls were recruited from the outpatients department of China-Japan Friendship Hospital.The cross-sectional area(CSA)、intra-balloon pressure (IBP)and compliance(（Δv/Δp）of each were measured by endoscopy in combination with EndoFlip. Results With the increase of balloon volume,the compliance of gastroesophageal junction in NERD group was significantly higher than that of control group（p<0.01） while the cross sectional area and intra-balloon pressure were similar.Conclusion Increased compliance of the gastroesophageal junction might be a factor in the pathogenesis of non-erosive reflux disease.

Key words: Key words: non-erosive reflux disease, compliance, gastroesophageal junction

刘继喜赵树巧刘芳李晓讴李靖涛. 非糜烂性反流病患者胃食管交界顺应性增加[J]. 基础医学与临床, 2017, 37(5): 714-717.