基础医学与临床 ›› 2017, Vol. 37 ›› Issue (3): 405-409.

• 短篇综述 • 上一篇    下一篇

自噬在肠黏膜屏障功能作用机制的研究进展

王彬彬,武承凤,张方信   

  1. 兰州总医院
  • 收稿日期:2016-03-14 修回日期:2016-06-03 出版日期:2017-03-05 发布日期:2017-02-23
  • 通讯作者: 张方信 E-mail:zhangfx59@126.com
  • 基金资助:
    高原缺氧大鼠肠上皮细胞损伤的自噬调控效应及其分子机制

Research progress on mechanism of autophagy in intestinal mucosal barrier function

  • Received:2016-03-14 Revised:2016-06-03 Online:2017-03-05 Published:2017-02-23

摘要: 自噬是细胞通过膜囊泡结构降解胞质内大分子物质和受损细胞器维持机体稳态的生物学过程。在肠黏膜屏障功能发生障碍过程中,自噬对于维持肠上皮细胞的存活起关键性作用。负调控自噬可导致肠道炎症和肿瘤的发生。

关键词: 自噬, 肠黏膜屏障, PI3K/Akt/mTOR信号通路, MicroRNA, Wnt/β-catenin信号通路

Abstract: Autophagy is a biological process which cells maintain homeostasis through degradation of cytoplasmic macromolecules and damaged organelles by membrane vesicle structure. Autophagy plays a critical role in maintaining survival of intestinal epithelial cells during intestinal mucosal barrier dysfunction. A negative regulator of autophagy can lead to intestinal inflammation and tumorigenesis.

Key words: Autophagy, Intestinal mucosal barrier, PI3K/Akt/mTOR signaling pathway, MicroRNA, Wnt/β-catenin signaling pathway

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