基础医学与临床 ›› 2016, Vol. 36 ›› Issue (9): 1295-1300.
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陈冉冉1,付玉荣2,伊正君3
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摘要： 环状RNA是最近发现的一类内源性非编码RNA，由内含子配对驱动的环化等模型产生，受相关调控因子调控。环状RNA的一个重要生物学功能是作为miRNA海绵，使miRNA水平在短时间内发生明显改变。环状RNA与疾病密切联系，是具有诊断和治疗潜力的分子。本文论述环状RNA的生物合成及调控、环状RNA的生物学功能以及环状RNA与疾病的关系。
关键词: 环状RNA, 非编码RNA, 内含子配对驱动的环化, miRNA海绵
Abstract: Circular RNA is a recently discovered endogenous non-coding RNA, which is generated by the model of intron-pairing-driven circularization and is regulated by the relevant regulatory factors. One of the important biological functions of circular RNA is as a miRNA sponge, which makes the level of miRNA changed significantly in a short time. The circular RNA is closely related to the disease, which is a potential molecular of diagnosis and treatment. This paper deals with the three aspects of the biosynthesis and regulation of circular RNA, the biological function of circular RNA and the relationship between circular RNA and diseases.
Key words: circular RNA, non-coding RNA, intron-pairing-driven circularization, miRNA sponge
陈冉冉 付玉荣 伊正君. 环状RNA与疾病关系的研究进展[J]. 基础医学与临床, 2016, 36(9): 1295-1300.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2016/V36/I9/1295
