基础医学与临床 ›› 2015, Vol. 35 ›› Issue (3): 409-412.
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刘欢欢,陈曦,余树民,宋品,沈留红,曹随忠,左之才,马晓平
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摘要： 睾丸中的胶质细胞源神经营养因子由支持细胞、管周细胞、精母细胞和球形精子合成和分泌，是调节精原干细胞自我更新和分化的关键因子；GDNF通过与SSCs膜上受体GFRα1结合形成GDNF- GFRα1复合物，再结合并活化RET，最后激活MAPK、SFK和PI3K-AKT信号通路并达到调控SSCs自我更新和分化的目的。
关键词: 胶质细胞源神经营养因子（GDNF）, 精原干细胞, 自我更新, 哺乳动物
Abstract: Glial cell line-derived neurophic factor(GDNF) is secreted by sertoli cells, peritubular myoid cells, spermatocytes and roud spermatids in testes, is a critical component during self-renwal of spermatogonial stem cells(SSCs) self-renewal. GDNF binds to GFRα1, expressed on the surface of SSCs, to form a heterodimer complex. As a consequence, this complex via activation of RET, triggers MAPK, SFK and PI3K-ATK signaling pathway to regulate SSCs self-renewal and differentiation.
Key words: GDNF, spermatogonial stem cells, self-renewal, mammalian
刘欢欢 陈曦 余树民 宋品 沈留红 曹随忠 左之才 马晓平. 以GDNF为核心的哺乳动物精原干细胞调控网络[J]. 基础医学与临床, 2015, 35(3): 409-412.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2015/V35/I3/409
