关键词: 非霍奇金淋巴瘤, 慢性病贫血, hepcidin, 白介素-6, 肿瘤坏死因子-α

Abstract: Objective The role of monocytes hepcidin in NHL patients.Methods Collecting the clinical information and peripheral venous blood of non-Hodgkin’s lymphoma patients.Serum concentration of IL-6 and TNF-α was detected by ELISA. Peripheral blood monocytes were isolated by CD14+ Magnetic beads.Hepcidin, IL-6 and TNF-α mRNA of monocytes were detected by Real time PCR quantitative assay.Results In NHL patients, hemoglobin was reduced(112.5±21.7g/l),monocyte hepcidin expression was higher than normal（P=0.013）.Monocyte hepcidin in untreated patients was negatively correlated with Hb and IL-6 levels(P<0.05),but not associated with TSAT%, SF and TNF-α levels.Conclusions The increased monocyte hepcidin in untreated lymphoma patients may play an etiologic role in ACD.

Key words: non-Hodgkin’s lymphoma, anemia of chronic disease, hepcidin, interleukin 6, tumor necrosis factor α