基础医学与临床 ›› 2014, Vol. 34 ›› Issue (6): 787-791.

• 研究论文 • 上一篇    下一篇

视交叉上核损毁对小鼠疼痛日节律行为的影响

张靖1,阴彬1,孙中生2,彭小忠3   

  1. 1. 中国医学科学院基础医学研究所
    2. 中国科学院北京生命科学研究院
    3. 中国医学科学院基础医学研究所&北京协和医学院 基础学院 生物化学与分子生物学
  • 收稿日期:2014-03-27 修回日期:2014-04-15 出版日期:2014-06-05 发布日期:2014-05-26
  • 通讯作者: 彭小忠 E-mail:peng_xiaozhong@163.com
  • 基金资助:
    IRES在翻译水平上介导的ADAR1表达上调影响神经胶质瘤发生发展的机制

Suprachiasmatic nucleus lesion induced abnormal rhythm of circadian inflammatory pain

  • Received:2014-03-27 Revised:2014-04-15 Online:2014-06-05 Published:2014-05-26
  • Contact: Xiao-zhong PENG E-mail:peng_xiaozhong@163.com

摘要: 目的 通过建立视交叉上核(SCN)损毁实验建立小鼠节律调控中枢失能模型,观察中枢节律控制中心SCN对疼痛节律行为的影响。方法 1)12小时 (h) 光照/12小时黑暗条下观察小鼠甲醛诱导的炎性痛反应的节律波动; 2)SCN损毁建立小鼠节律中枢失能模型,观察小鼠转轮节律行为紊乱; 3)观察SCN损毁后小鼠甲醛诱导的炎性痛日节律波动特征的改变。结果1)12h光照/12h黑暗条下小鼠的甲醛诱导炎性痛存在日节律波动; 2)SCN损毁后小鼠正常的炎性痛日节律波动特点明显改变,出现活动期与静息期波动峰值的反转。结论 提示脑内的节律调控中枢SCN对小鼠炎性痛的节律波动具有中枢调控作用。

关键词: 疼痛, 福尔马林, 炎性痛, 视交叉上核, 日节律

Abstract: Objective To investigate the regulation of suprachiasmatic nucleus (SCN) on the inflammatory pain in mice at behavioral level. Methods Wheel running of circadian behavioral monitor system, the surgery of SCN lesion and the formalin induced nociceptive responses test were employed to analyze if the synchronize and/or maintain circadian function of SCN could modulate the rhythm of inflammatory pain induced by formalin in mice. Results Our results showed that the formalin induced inflammatory nociceptive responses were shown a circadian oscillation pattern in resting phase (ZT4) and active phase (ZT20), and after SCN lesion, the mice were shown an overturned pattern of nociceptive responses between ZT4 and ZT20 compared with normal control. Conclusions The circadian synchronized function is an important regulator for maintaining normal daily fluctuation patterns of inflammatory pain induced by formalin.

Key words: pain, formalin, inflammatory pain, SCN, circadian rhythm

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