基础医学与临床 ›› 2014, Vol. 34 ›› Issue (3): 426-429.
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王敏,王立茹
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摘要: 转化生长因子β(TGF-β)是造血细胞生长的负调控因子,TGF-β/SMAD信号途径在造血系统恶性肿瘤的发生中起到重要的作用,TGF-β表达及受体或受体后水平缺陷都可导致造血细胞的恶性增殖。深入研究该信号通路对于探寻造血系统恶性肿瘤的发病机制及开发以该通路环节为靶点的靶向治疗具有积极意义。
关键词: 转化生长因子β, 信号通路, 造血系统, 肿瘤
Abstract: Transforming growth factor β (TGF-β) is a negative regulated cytokine for growth of hematopoietic cells. TGF-β/SMAD signaling pathway takes important part in pathogenesis of hematopoietic malignance diseases. The deficiencies of TGF-β expression and mutations of TGF-β receptors or downstream signaling pathways can cause malignant proliferation of hematopoietic cells. To study the signaling pathway of TGF-β may attribute to the recognize of the pathogenesis of hematopoietic malignances and the development of therapy targeting the TGF-β pathway.
Key words: TGF-β, signaling, hematopoietic, malignance
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R733.3
王敏 王立茹. TGF-β信号通路与造血系统肿瘤[J]. 基础医学与临床, 2014, 34(3): 426-429.
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