基础医学与临床 ›› 2013, Vol. 33 ›› Issue (5): 627-630.
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倪伟1,王浩宇1,刘涛2
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摘要: 神经轴突导向分子Slit3是近年发现的分泌型细胞外基质蛋白,基因功能研究表明,Slit3对神经元的发育并非必要,但对非神经细胞相关发育过程却是必须的。目前研究认为Slit3也是一个新的血管生成因子,对细胞迁移、血管生成、器官发育、生殖调节以及肿瘤和精神疾病的发生等多种生命活动具有重要作用。
关键词: 轴突导向分子, Slit3, 细胞迁移, 血管生成, 器官发育
Abstract: The axon guidance molecule Slit3 is a secreted extracellular matrix protein that was found in recent years. Genetic function studies revealed that Slit3 is dispensable for neural development but required for non-neuron-related developmental. Recent study suggests that Slit3 is a new angiogenic factor implicated in regulating a variety of life activities, such as cell migration, angiogenesis, organogenesis, reproductive regulation, tumourigenesis and mental disease.
Key words: axon guidance molecule, Slit3, cell migration, angiogenesis, organogenesis
中图分类号:
R331.32
倪伟 王浩宇 刘涛. 神经轴突导向分子Slit3功能研究进展[J]. 基础医学与临床, 2013, 33(5): 627-630.
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