基础医学与临床 ›› 2013, Vol. 33 ›› Issue (10): 1345-1347.

• 短篇综述 • 上一篇    下一篇

COX-2非依赖性途径介导的阿司匹林抗癌作用

丁江华1,刘玉琴1,袁利亚2,陈国安1   

  1. 1. 南昌大学第一附属医院
    2. 江西省医学科学研究院
  • 收稿日期:2012-11-09 修回日期:2012-12-27 出版日期:2013-10-05 发布日期:2013-09-25
  • 通讯作者: 陈国安 E-mail:doctor0922@126.com

The antitumor activity of aspirin via COX-2-independent pathways

  • Received:2012-11-09 Revised:2012-12-27 Online:2013-10-05 Published:2013-09-25

摘要: 新近发现阿司匹林(ASA)具有抗癌作用。除经典的抑制环氧化酶-2(COX-2)抗癌途径外,ASA还存在更重要的COX-2非依赖途径,即诱导NOS生成、调节NF-κB与Bcl-2家族、抑制Akt、mTOR与ERK活性等。其抗癌作用因肿瘤细胞类型而异,在同一肿瘤细胞中也因诱导因子不同而作用不同。总之,ASA的抗癌机制存在多样化现象,且具细胞类型特异性。

关键词: COX-2非依赖性, 阿司匹林, 抗癌作用

Abstract: Recently, aspirin (ASA) has been found to be of antineoplastic activity. Apart from the classical pathway of inhibiting cyclooxygenase-2 (COX-2), there are major COX-2-independent pathways governing the anticancer mechanisms of ASA, including induction of nitric oxide synthase (NOS), regulation of NF-κB pathway and the Bcl-2 family, together with inhibition of Akt, mTOR and ERK activation. Of note, ASA’s antitumor activity varies in different types of cancer cells. In the same cancer cell, ASA triggers apoptosis via different pathway induced by distinct factors. Overall, the anticancer effects of ASA are diversified and cell-type specific.

Key words: COX-2-independent pathways, Aspirin, anticancer activity

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