改良的超长方案在PCOS不孕患者IVF/ICSI-ET中的疗效

基础医学与临床 ›› 2010, Vol. 30 ›› Issue (9): 984-987.

改良的超长方案在PCOS不孕患者IVF/ICSI-ET中的疗效

龚斐罗克莉卢光琇

中南大学与干细胞工程研究所；中信湘雅生殖与遗传专科医院中南大学生殖与干细胞工程研究所；中信湘雅生殖与遗传专科医院中南大学生殖与干细胞工程研究所

收稿日期:2010-06-01 修回日期:2010-07-06 出版日期:2010-09-05 发布日期:2010-09-05
通讯作者: 卢光琇

A Modified Ultra-long Down-regulation Protocol for Infertile Patients with PCOS in IVF/ICSI-ET

Fei GONG, Ke-li LUO, Guang-xiu LU

Institute of Reproductive and Stem Cell Engineering, Central South University Reproduction and Stem cells Engineering Institution, Central South University

Received:2010-06-01 Revised:2010-07-06 Online:2010-09-05 Published:2010-09-05
Contact: Guang-xiu LU

摘要/Abstract

摘要： 目的：比较改良超长方案降调节结合人绝经期促性腺激素（HMG）和常规长方案降调节在多囊卵巢综合征（PCOS）不孕患者行体外受精 /胞浆内单精子注射-胚胎移植术 (IVF/ICSI-ET) 助孕中的疗效。方法：回顾分析我院2008年8月至2009年12月采用改良超长方案的132例和常规长方案588例PCOS患者，对两组受精率、卵裂率、临床妊娠率、着床率、抱婴率、流产率、治疗费用等重要指标进行统计和对比。结果：与常规长方案组相比，改良超长方案组患者的受精率、卵裂率、着床率、临床妊娠率显著上升(P<0.001)；用药天数缩短且患者治疗费用显著减少(P<0.001)；抱婴率上升、流产率下降（P＜0.05)。结论：改良超长方案结合HMG超排卵能有效改善PCOS不孕患者行 IVF/ICSI-ET 的妊娠结局并节约治疗费用。

关键词: 多囊卵巢综合症, 超长降调方案, IVF/ICSI-ET

Abstract: Objectives To compare and analyze the effect of two controlled ovarian stimulation (COH) protocols (Modified ultra-long down-regulation protocol vs. conventional long down-regulation protocol) for In Vitro Fertilization / Intracytoplasmic Sperm Injection - Embryo Transfer (IVF/ICSI-ET) treatment in infertility patients with Polycystic Ovarian Syndrome (PCOS).Methods 132 IVF/ICSI-ET cycles utilizing modified ultra-long down-regulation protocol and 588 IVF/ICSI-ET cycles underwent conventional long down-regulation protocol during August 2008 to December 2009 were retrospectively analyzed. Several key parameters of the two COH protocols, including: fertilization and cleavage rate, clinical pregnancy rate, live birth rate, abortion rate, treatment duration and therapeutic expenses etc. were compared and analyzed. Results In modified ultra-long down-regulation protocol, the fertilization and cleavage rate, clinical pregnancy rate and implantation rate were significantly increased, P<0.001, as well for the live birth rate (P<0.05), the abortion rate (P<0.05) and the progesterone level on the day of HCG injection were decreased (P<0.001). In the mean while, the treatment duration was shortened (P<0.001), and treatment cost were reduced (P<0.001), when compared to conventional long protocol. Conclusion Modified super-long protocol plus hMG for PCOS infertile patients saved the therapeutic cost and raised the success rate of ART.

Key words: PCOS, ultra-log down-regulation protocol, IVF-ET

龚斐罗克莉卢光琇. 改良的超长方案在PCOS不孕患者IVF/ICSI-ET中的疗效[J]. 基础医学与临床, 2010, 30(9): 984-987.

Fei GONG; Ke-li LUO; Guang-xiu LU. A Modified Ultra-long Down-regulation Protocol for Infertile Patients with PCOS in IVF/ICSI-ET[J]. Basic & Clinical Medicine, 2010, 30(9): 984-987.