关键词: 蒙古族, 原发性高血压, 胆固醇脂转移蛋白, TaqⅠB基因多态性

Abstract: Objective To explore the association of cholesteryl ester transfer protein gene TaqⅠB polymorphism with Essential Hypertension in Chinese Mongolian population. Methods A total of 1819 Mongolian people, including 840 hypertensive patients and 979 normal controls from agriculture and pastoral areas in Tongliao city of Inner Mongolia, were included in this case-control study. We identified the genotypes of CETP TaqⅠB with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and direct sequencing technology. Results The frequency distributions of CETP gene TaqⅠB locus genotypes and alleles in men, women, and the whole population, were in accordance with the Hardy-Weinberg equilibrium. The differences of TaqⅠB locus genotypes and alleles frequency distributions between Essential Hypertension and healthy controls were not statistically significant in men, women, and the total population. In the male group, the individuals carrying AA genotype had higher high-density lipoprotein cholesterol level and lower total cholesterol and triglyceride levels, compared to those with GG genotype (P <0.05). Conclusion CETP gene TaqⅠB polymorphism may not be a direct risk factor for essential hypertension, but it can affect the blood lipid levels, might be indirectly involved in the pathogenesis of Essential Hypertension.

Key words: Mongolian, Essential Hypertension, cholesterol ester transfer protein, TaqⅠB gene polymorphism