特发性肺纤维化患者血硫化氢水平下降

基础医学与临床 ›› 2010, Vol. 30 ›› Issue (2): 122-124.

特发性肺纤维化患者血硫化氢水平下降

孙丹房立平耿彬刘新民唐朝枢

北京大学第一医院北京大学第一医院心血管研究所北京大学第一医院老年内科北京大学第一医院心血管病研究所

收稿日期:2009-03-23 修回日期:2009-07-03 出版日期:2010-02-05 发布日期:2010-02-05
通讯作者: 刘新民

Serum hydrogen sulfide reduced in idiopathic pulmonary fibrosis patients

Dan SUN, Li-ping FANG, Bin GENG, Xin-min LIU, Chao-shu TANG

Peking University the First Hospital Institute of Cardiovascular Research, Peking University the First Hospital Department of Geriatrics,Peking University the First Hospital Institute of Cardiovascular Research, Peking University First Hospital

Received:2009-03-23 Revised:2009-07-03 Online:2010-02-05 Published:2010-02-05
Contact: Xin-min LIU,

摘要/Abstract

摘要： 目的探索特发性肺纤维化(IPF)患者疾病过程中内源性硫化氢(H2S)的变化及其意义，及其与IPF疾病严重程度的关系。方法将研究对象分为IPF组和对照组，检测各组血浆H2S含量。对IPF组行动脉血氧分压、红细胞沉降率(ESR)、C反应蛋白(CRP)、乳酸脱氢酶(LDH)、肺功能及高分辨CT(HRCT)检查；测定IPF组患者在症状急性加重和缓解时血浆H2S含量。结果 ⑴IPF组血浆H2S含量明显低于对照组（P﹤0.01）；⑵IPF组血浆H2S含量在急性加重时明显高于症状缓解时（P﹤0.01）。⑶IPF组患者随影像学病变进展，血浆H2S含量无明显下降。结论内源性H2S可能参与了IPF的疾病过程，可能与疾病的严重程度相关。

关键词: 特发性肺纤维化, 硫化氢

Abstract: Objective To explore the effect of endogenous H2S in Idiopathic Pulmonary Fibrosis(IPF) patients, and its relationship with the severity of IPF. Methods Plasma H2S in 27 patients with IPF（IPF group）and 28 healthy physical examination people (control group) were tested. PaO2，ESR，CRP，LDH，HRCT and lung function in IPF group were tested to evaluate the severity of the disease at the same time. Then the concentrations of H2S in aggravating and palliative period in IPF group were observed. Results ⑴ Compared with the control group, the concentration of plasma H2S in IPF group was reduced significantly (P﹤0.01). ⑵The concentration of H2S in aggravating period was higher than palliative period (P﹤0.01). ⑶With the progress of HRCT，there was a descending trend of plasma H2S (P>0.05). Conclusion Endogenous H2S was probably involved in the course of IPF, and was associated with the progress of the disease.

Key words: Idiopathic Pulmonary Fibrosis, Hydrogen Sulfide

孙丹房立平耿彬刘新民唐朝枢. 特发性肺纤维化患者血硫化氢水平下降[J]. 基础医学与临床, 2010, 30(2): 122-124.

Dan SUN; Li-ping FANG; Bin GENG; Xin-min LIU; Chao-shu TANG. Serum hydrogen sulfide reduced in idiopathic pulmonary fibrosis patients[J]. Basic & Clinical Medicine, 2010, 30(2): 122-124.

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