基础医学与临床 ›› 2009, Vol. 29 ›› Issue (3): 326-329.
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张颖 吴欣怡
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Ying ZHANG, Xin-yi WU
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摘要: 糖尿病患者角膜创伤愈合延迟可能与角膜细胞中MAPK信号通路活化、TGF-β信号通路传导减弱、胰岛素信号通路相关基因表达异常及胰岛素受体表达下降有关联。此外, NF-κb炎性通路以及细胞色素C凋亡通路异常激活,也对糖尿病角膜创伤愈合产生不利影响。本文旨在综述糖尿病角膜创伤愈合过程中相关信号通路的研究进展。
关键词: 信号通路, 角膜创伤愈合, 糖尿病
Abstract: Delayed wound healing in diabetic cornea may be associated with the activation of MAPK signal pathway, impaired signal transduction of TGF-β signal pathway, abnormal expression of genes related to insulin signal pathway and reduced expression of insulin receptor. In addition, the activation of NF-κb and cytochrome C signal pathway also has harmful influence on delayed wound healing. This paper reviews research progress about signal pathway of delayed wound healing in diabetic cornea.
Key words: Signal pathway, corneal wound healing, diabetes mellitus
张颖 吴欣怡. 糖尿病角膜创伤愈合过程中信号通路的研究进展[J]. 基础医学与临床, 2009, 29(3): 326-329.
Ying ZHANG; Xin-yi WU. Research Progress in Signal Pathway of Corneal Wound Healing in Diabetes Mellitus[J]. Basic & Clinical Medicine, 2009, 29(3): 326-329.
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