基础医学与临床 ›› 2009, Vol. 29 ›› Issue (11): 1203-1206.

• 研究论文 • 上一篇    下一篇

血管生成素-2和内皮抑素在子宫内膜异位症中的高表达

范俊 董文韬 孙宝治 李晓林 刘波 王纯   

  1. 山东省青岛市市立医院
  • 收稿日期:2008-08-06 修回日期:2008-12-26 出版日期:2009-11-20 发布日期:2009-11-20
  • 通讯作者: 范俊

High expression of angiopoietin-2 and endostatin in endometriosis

Jun FAN, Wen-tao DONG, Bao-zhi SUN, Xiao-lin LI, Bo LIU, Chun WANG   

  1. Qing Dao Municipal Hospital
  • Received:2008-08-06 Revised:2008-12-26 Online:2009-11-20 Published:2009-11-20
  • Contact: Jun FAN,

摘要: 目的 探讨血管生成素-2(ANG-2)和内皮抑素(ENS)在子宫内膜异位症发生发展中的作用。方法 卵巢子宫内膜异位症病人25例,24例无内膜病变者为对照组。留取子宫内膜,用免疫组化染色法检测ANG -2和ENS在子宫内膜中的表达,用酶联免疫吸附测定法检测腹腔液中ANG -2和ENS的蛋白含量。结果ANG -2在位子宫内膜组织中的阳性表达率显著高于异位内膜和对照组,异位内膜中阳性表达率显著高于对照组;ENS在异位内膜组织中的表达明显高于在位内膜和对照组,在位内膜明显高于对照组;ANG-2及ENS表达强度在子宫内膜异位症Ⅰ、Ⅱ期与Ⅲ、Ⅳ比较无显著差异。异位组腹腔液的ANG-2、ENS含量和ANG-2/ENS 比值均显著高于对照组。结论ANG-2和ENS在子宫内膜异位症血管生成中起到重要的作用,参与调节异位病灶的发生和进展。

关键词: 血管生成素-2, 内皮抑素, 子宫内膜异位症, 腹腔液, 血清, 血管生成素-2, 内皮抑素, 子宫内膜异位症, 腹腔液, 血清

Abstract: Objective To explore the effect of Angiopoietin-2(ANG-2) and Endostatin (ENS) in genesis and development of endometriosis.Methods 25 endometriosis cases were enrolled into present study.24 patients without endometriosis were selected control. ANG-2 and ENS in endometrium were detected by Immunohistochemistry. The concentrations of ANG-2 and ENS in peritoneal fluid were determinated with enzyme linked immunoabsorbant assay.Results In the EMs group ,the ANG-2 positive rate in eutopic endometrium was significantly higher than that of ectopic endometrium . The ANG-2 positive rate in ectopic endometrium was significantly higher than that of control group;In EMs group, The ENS positive rate in ectopic endometrium was significantly higher than that of eutopic endometrium .The ENS positive rate in eutopic endometrium was significantly higher than that of control group. There was no significant difference of ANG-2 or ENS between stageⅠ~Ⅱand stage Ⅲ~Ⅳ. In peritoneal fluid, ANG-2 and ENS concentration and ratio of ANG-2/ENS in endometriosis were significantly higher than that in controls. Conclusion The effect of angiopoietin-2 and endostatin in angiogenesis of endometriosis are important and adjust to pathogenesis and development of the endometriosis .

Key words: ngiopoietin-2, Endostatin, endometriosis, ngiopoietin-2, Endostatin, endometriosis, peritoneal fluid, serum

中图分类号: