基础医学与临床 ›› 2008, Vol. 28 ›› Issue (8): 890-893.

• 短篇综述 • 上一篇    下一篇

树突细胞源肿瘤疫苗

王薇 杨先达   

  1. 中国协和医科大学 基础医学院 病理生理学系
  • 收稿日期:2007-09-24 修回日期:2007-10-29 出版日期:2008-08-25 发布日期:2008-08-25
  • 通讯作者: 王薇

Dendritic cell-based tumor vaccine

Wei WANG, Xian-da YANG   

  1. Institute of Basic Medical Sciences,CAMS & PUMC
  • Received:2007-09-24 Revised:2007-10-29 Online:2008-08-25 Published:2008-08-25
  • Contact: Wei WANG,

摘要: 树突细胞(DC)作为免疫应答的核心环节,具有强大的专职抗原提呈而引起免疫应答的能力,比之传统的直接免疫疗法,将DC在体外进行制备再回输入体内,能作为最佳的抗原提呈细胞而更好的刺激抗瘤免疫应答,是有效的细胞免疫疗法,已被越来越多的应用于肿瘤疫苗的制备。

Abstract: As the central component of immune response, dendritic cells (DCs) are the most powerful antigen presenting cells. Compared with the conventional direct vaccination, ex vivo treatment of the DCs with tumor antigens generates more potent APC to stimulate antitumor response in vivo. This efficient cellular immuno-therapy is gaining increasing popularity in tumor vaccine preparation.