基础医学与临床 ›› 2008, Vol. 28 ›› Issue (5): 516-518.

• 短篇综述 • 上一篇    下一篇

星形胶质细胞在帕金森病发病机制中的作用

吕风月 赵咏梅   

  1. 首都医科大学宣武医院 宣武医院脑老化研究室
  • 收稿日期:2007-10-12 修回日期:2007-12-05 出版日期:2008-05-25 发布日期:2008-05-25
  • 通讯作者: 赵咏梅

Roles of astrocytes in the pathogenesis of Parkinson's disease

  

  1. Xuanwu Hospital, Capital Medical University Xuanwu Hospital, Capital Medical University
  • Received:2007-10-12 Revised:2007-12-05 Online:2008-05-25 Published:2008-05-25

摘要: 帕金森病是中老年人常见的中枢神经系统变性疾病。星形胶质细胞可能参与了其发病过程,一方面,它可以通过释放神经营养因子、谷胱甘肽等保护多巴胺能神经元,在帕金森病中发挥保护作用;另一方面,它也可能通过释放一些促炎症因子而推动帕金森病的发生和发展。

Abstract: Parkinson's disease(PD) is a progressive neurodegenerative disorder affecting mainly the elderly. Astrocyte may be involved in the pathogenesis of PD. On the one hand, it may play a protective role in PD by releasing neurotrophic factors and glutathione to support the survival of dopaminergic neurons. On the other hand, astrocyte may also release proinflammatory cytokines to promote the development of PD.