基础医学与临床 ›› 2008, Vol. 28 ›› Issue (4): 400-402.
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谢谨捷 杨娅
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Jin-jie XIE, Ya YANG
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摘要： ApoE和LDL-R基因敲除鼠可自发形成动脉粥样硬化斑块，是动脉粥样硬化研究的常用模型。在此基础上应用基因打靶技术建立的白介素-1、C反应蛋白、清道夫受体、IgG Fc、补体C1q及CD44等模型对研究动脉粥样硬化中炎症和免疫因子的作用机制起了重要作用。
关键词: 基因敲除小鼠, 动脉粥样硬化, 致病机制
Abstract: The ApoE and LDL-R knock out mouse may developed atherosclerosis spontaneously and were applied to research on atherosclerosis widely. On the basis of these mouse model, the model generated by gene targeting , like IL-1, C-reactive protein, scavenger receptor, IgG Fc,C1q and CD44, have played an important role in studing effects of inflammatory factor and immune factor on atherosclerosis.
Key words: knock-out mice, atherosclerosis, pathogenic mechanism
谢谨捷 杨娅. 应用基因敲除鼠研究动脉粥样硬化[J]. 基础医学与临床, 2008, 28(4): 400-402.
Jin-jie XIE; Ya YANG. Application of Knock Out Mice in Research of Atherosclerosis[J]. Basic & Clinical Medicine, 2008, 28(4): 400-402.
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