Abstract: Objective: To evaluate the effect of Integrative therapy and influencing factors in patients with intractable constipation (IC). Methods: Eighty-four consecutive IC patients were divided into non overlap and overlap groups. All patients received individualized integrative therapeutic regimen for 4 weeks. The symptom scores of constipation and total effective rates were evaluated. And influencing factors of therapeutic effect in IC were analyzed. Results: (1) IC of overlap group and non overlap group accounted for 40.5% (34/84) and 59.5% (50/84) respectively. (2)The total effective rates were 50.0% and 78.0% in overlap and non-overlap group, respectively (P<0.05). (3) Thirty-seven patients received psychological assessment and 59.4% (22/37) of them had psychological dysfunctions. The total effective rates were 4.8% and 31.5% in overlap and non overlap group with psychological dysfunctions, respectively (P<0.05). Conclusions: The integrative individualized therapies were effective to relieve symptoms in patients with IC. However, overlap symptoms, and psychological dysfunction influenced the efficacy of treatment.