基础医学与临床 ›› 2008, Vol. 28 ›› Issue (10): 1111-1116.

• 短篇综述 • 上一篇    

Caveolin-1在肿瘤中的表达及临床意义

董伟家 张建国 杨景武 张博   

  1. 湖州师范学院医学院基础医学部
  • 收稿日期:2008-01-02 修回日期:2008-02-09 出版日期:2008-10-25 发布日期:2008-10-25
  • 通讯作者: 董伟家

Expression of Caveolin-1 in tumor and Clinical significance

Wei-jia DONG, Jian-guo ZHANG, Jing-wu YANG, Bo ZHANG   

  1. Huzhou Teachers College Medical School
  • Received:2008-01-02 Revised:2008-02-09 Online:2008-10-25 Published:2008-10-25
  • Contact: Wei-jia DONG,

摘要: 小窝蛋白(Cav-1)是一种细胞质膜微囊(caveolae)表面标记蛋白,通过与细胞的黏附分子和信号受体相互作用调整肿瘤发生。多方面的证据显示了它在不同的肿瘤中有不一样的表达,而近年有人把它作为一诊疗标志来研究,相信将来会开辟一条抗肿瘤治疗的新途径。

关键词: 细胞质膜微囊, 小窝蛋白, 肿瘤

Abstract: Caveolin-1 (Cav-1) is a scaffold protein of caveolae that acts as a tumor modulator by interacting with cell adhesion molecules and signaling receptors. Evidence from a variety of studies indicate that caveolin-1 exhibits the heterogeneity of Cav-1 expression in different tumors. Current research has clearly established a role for Cav-1 as a a novel prognostic marker, Future studies will undoubtedly offer novel exciting opportunities to develop anti-cancer therapies.

Key words: caveolae, caveolin-1, tumor

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