基础医学与临床 ›› 2007, Vol. 27 ›› Issue (9): 1063-1065.
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宋宝 宋现让 魏玲 魏玲
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Bao Song Xian-rang Song Jie Liu Ling Wei
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摘要： microRNAs(miRNAs)是人类新发现的一类非编码小分子RNA，广泛分布于真核细胞内。miRNAs通过与靶基因互补位点配对结合，在转录后水平负性调控靶基因的表达，参与生长发育、细胞增殖、细胞凋亡、细胞分化等生命过程。据推测，大约1%的人类已知基因编码miRNAs，而miRNAs可调控人类基因组中10%~30%的基因。本文就如何识别miRNAs及其靶基因作一简要介绍。
关键词: microRNA, 靶mRNA, 非编码RNA
Abstract: MicroRNAs (miRNAs) are a recently discovered family of small non-coding RNAs, which exist in eukaryotes and regulate gene expression post-transcriptionally by binding to complementary sites on target mRNAs. MiRNAs play important roles in regulation of cell proliferation, development, apoptosis and cell differentiation. It's predicted that about 1% human known genes encode microRNAs and microRNAs may regulate 10~30%of the genes within the human genome. Here we focus on the knowledge about how to recognize miRNAs and identify their target mRNAs.
Key words: microRNA, target mRNA, Non-coding miRNA
宋宝 宋现让 魏玲 魏玲. miRNAs及其靶基因的识别[J]. 基础医学与临床, 2007, 27(9): 1063-1065.
Bao Song Xian-rang Song Jie Liu Ling Wei. Recognition of MicroRNAs and its-targeting genes[J]. Basic & Clinical Medicine, 2007, 27(9): 1063-1065.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2007/V27/I9/1063
