关键词: 胰腺癌, 临床特点, CA19-9, 治疗

Abstract: Aims To analyze and summarize the clinical characteristics and to evaluate the laboratory tests and therapeutic methods of pancreatic carcinoma, in order to improve the level of recognizing the pancreatic carcinoma. Methods 300 cases of pancreatic carcinoma were collected during 1995～2003 from PUMCH. Results ①The clinical presentations included weight loss(75.3%), abdominal pain (66.3%), anorexia(51.0%), jaundice(50.0%), abdominal distention(44.0%), back pain(18.0%), diarrhea(14.3%) and melena(7.7%) .②The sensitivities of tumor markers to diagnose pancreatic cancer were 77.5% of CA19-9, 66.0% of CA50, 48.3% of CA242 and 29.7% of CEA. If CA19-9 combined with CA50, CA242 and CEA, its sensitivity was increased to86.0% .③The titer value of CA19-9 was significantly related with radical operation ratio(P<0.05), but it was not related to metastasis of lymph node and the tumor location either in pancreatic or bile duct . ④CA19-9 had significantly influenced by bilirubin at 37u/ml, but it didn't at 150,240 and 500u/ml.⑤ The therapeutics used were radical operation(30.7%), palliative operation(27.3%) and non-operation (42%). Conclusion The titer value of CA19-9 may be interfered with bilirubin .It is important for early diagnose to learn clinical characteristics of pancreatic carcinoma and to apply correctly diagnostic methods.

Key words: Pancreatic carcinoma, Clinical features, CA19-9, Treatment