基础医学与临床 ›› 2023, Vol. 43 ›› Issue (2): 341-345.doi: 10.16352/j.issn.1001-6325.2023.02.341

• 短篇综述 • 上一篇    下一篇

中性粒细胞在COVID-19发生发展中作用的研究进展

王亮, 司萍, 沈永明, 崔晓鸣*   

  1. 天津市儿童医院/天津大学儿童医院 检验科,天津 300074
  • 收稿日期:2021-12-30 修回日期:2022-04-07 出版日期:2023-02-05 发布日期:2023-02-02
  • 通讯作者: *34165823@qq.com

Role of neutrophils in the development and progression of COVID-19

WANG Liang, SI Ping, SHEN Yongming, CUI Xiaoming*   

  1. Department of Clinical Laboratory, Tianjin Children's Hospital/Children's Hospital of Tianjin University,Tianjin 300074, China
  • Received:2021-12-30 Revised:2022-04-07 Online:2023-02-05 Published:2023-02-02
  • Contact: *34165823@qq.com

摘要: 中性粒细胞是COVID-19感染中出现较多的固有免疫细胞。中性粒细胞数量以及血浆中性粒细胞胞外诱捕网(NETs)水平与COVID-19严重程度呈正相关。本文综述中性粒细胞以及NETs的生成与降解参与COVID-19的病理过程,以期对深入研究COVID-19的发病机制以及疾病干预提供借鉴。

关键词: COVID-19, SARS-CoV-2, 中性粒细胞, 中性粒细胞胞外诱捕网

Abstract: Neutrophils are more innate immune cells found in coronavirus disease in 2019(COVID-19). The accounting of neutrophils and the level of plasma neutrophil extracellular traps(NETs) were positively correlated with the severity of COVID-19. This article reviews the relevant studies of neutrophils, formation and degradation of NETs involved in the pathological process of COVID-19, providing the reference for further studies of pathogenesis and intervention.

Key words: COVID-19, SARS-CoV-2, neutrophil, neutrophil extracellular traps

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