壳聚糖药用制剂及其应用的研究进展

doi:10.16352/j.issn.1001-6325.2022.11.1791

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (11): 1791-1794.doi: 10.16352/j.issn.1001-6325.2022.11.1791

壳聚糖药用制剂及其应用的研究进展

邹兴龙, 陈柱先, 孙娟娟, 蔡江滢, 苏露, 马薇, 傅思武^*

西北民族大学医学部,甘肃兰州 730030

收稿日期:2021-05-24 修回日期:2021-12-08 出版日期:2022-11-05 发布日期:2022-11-01
通讯作者: ^* yxfsw@xbmu.edu.cn
基金资助:
西北民族大学2020年本科生科研能力训练项目(XBMU-BYL20213);中央高校基本科研业务费创新团队项目(31920200001)

Research progress of application of pharmaceutical preparation chitosan

ZOU Xing-long, CHEN Zhu-xian, SUN Juan-juan, CAI Jiang-ying, SU Lu, MA Wei, FU Si-wu^*

Department of Medicine, Northwest Minzu University, Lanzhou 730030, China

Received:2021-05-24 Revised:2021-12-08 Online:2022-11-05 Published:2022-11-01
Contact: ^* yxfsw@xbmu.edu.cn

摘要/Abstract

摘要： 壳聚糖(CTS)作为自然界中唯一的碱性多糖,具有独特的生理活性、良好的成膜性、吸附性及抗菌性等特性。CTS及其衍生物的各种药用制剂和临床应用,证明了CTS产品在医药制剂领域的实用性,CTS及其衍生物在医药领域及临床应用中具有良好的发展前景。

关键词: 壳聚糖, 药用制剂, 药物载体, 临床应用

Abstract: As the only alkaline polysaccharide in nature, chitosan(CTS) is haracterized by its unique physiological activity, good film-forming capacity, well adsorption and antibacterial properties. Various pharmaceutical preparations and clinical applications of CTS and its derivatives have proved the practicability of CTS products in the field of pharmaceutical preparations. CTS and its derivatives have a good development prospect in the field of medicine and clinical application.

Key words: chitosan, medicinal preparations, drug carrier, clinical application

中图分类号:

Q539

邹兴龙, 陈柱先, 孙娟娟, 蔡江滢, 苏露, 马薇, 傅思武. 壳聚糖药用制剂及其应用的研究进展[J]. 基础医学与临床, 2022, 42(11): 1791-1794.

ZOU Xing-long, CHEN Zhu-xian, SUN Juan-juan, CAI Jiang-ying, SU Lu, MA Wei, FU Si-wu. Research progress of application of pharmaceutical preparation chitosan[J]. Basic & Clinical Medicine, 2022, 42(11): 1791-1794.

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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2022/V42/I11/1791

参考文献 25

[1]	Santos VP,Marques N,Maia P,et al. Seafood waste as attractive source of chitin and chitosan production and their applications[J]. Int J Mol Sci, 2020,21:4290-4291.
[2]	Popescu R, Ghica MV, Dinu-Pîrvu CE, et al. New opportunity to formulate intranasal vaccines and drug delivery systems based on chitosan[J]. Int J Mol Sci, 2020,21:5016-5021.
[3]	Aquino RP, Auriemma G, Conte GM, et al. Development of chitosan/mannitol microparticles as delivery system for the oral administration of a spirulina bioactive peptide extract[J]. Molecules, 2020,25:2089-2098.
[4]	Gka A, Dbka B, Eko C. et al. Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: formulation, miscibility, in vitro and in vivo studies[J]. Eur Polym J, 2019,116:311-320.
[5]	Kravanja, Primoi, Knez, et al. Chitosan-based (nano)materials for novel biomedical applications[J]. Molecules, 2019,24:1960-1961.
[6]	Ibrahim HM,Mostafa M, Kandile NG. Potential use of N-carboxyethyl chitosan in biomedical applications: Preparation, characterization, biological properties[J].Int J Biol Macromol,2020,149:664-671.
[7]	Wang S, Sun Y, Zhang J, et al. Astragalus polysaccharides/chitosan microspheres for nasal delivery: preparation, optimization, characterization, and pharmacodynamics[J]. Front Pharmacol, 2020,11:230-237.
[8]	Chen J,Pan H,Duan H, et al. Self-assembled liposome from core-sheath chitosan-based fibres for buccal delivery of carvedilol: formulation, characterization and in vitro and ex vivo buccal absorption[J]. J Pharm Pharmacol,2020,72:343-355.
[9]	Li J, Cheng T, Tian Q, et al. A more efficient ocular delivery system of triamcinolone acetonide as eye drop to the posterior segment of the eye[J]. Drug deliv,2019,26:188-198.
[10]	陈莉娅,李平,王建民.复方壳聚糖口腔溃疡涂膜剂的制备及临床应用[J].中国医院药学杂志,2001,1:50-51.
[11]	夏联恒,张珈源,王佳鑫,等.李令根应用中药壳聚糖复合药膜治疗下肢慢性溃疡经验[J].北京中医,2019,38:1096-1098.
[12]	Muthiah Pillai NS, Eswar K, Amirthalingam S, et al. Injectable nano whitlockite incorporated chitosan hydrogel for effective hemostasis[J].ACTS Applied Bio Materials,2019,2:865-873,
[13]	Wang XL, Xu PC, Yao ZX, et al. Preparation of antimicrobial hyaluronic acid/quaternized chitosan hydrogels for the promotion of seawater-immersion wound healing[J]. Front. Bioeng. Biotechnol,2019,7:360-379.
[14]	Li J, Zhuang S. Antibacterial activity of chitosan and its derivatives and their interaction mechanism with bacteria: current state and perspectives[J]. Eur Polym J,2020,138:109984.doi:10.1016/j.eurpolymj.2020.109984.
[15]	Feng P, Luo Y, Ke C, et al. Chitosan-based functional materials for skin wound repair: mechanisms and applications[J]. Front BioengBiotechnol,2021,9:650598.doi:10.3389/fbioe.2021.650598
[16]	Matica MA, Aachmann FL, Tndervik A, et al. Chitosan as a wound dressing starting material: antimicrobial properties and mode of action[J].Int J Mol Sci,2019,20:5892-5896.
[17]	Randy C, Tzi N, Jack W, et al.Chitosan:an update on potential biomedical and pharmaceutical applications[J].Mar Drugs,2015,13:5156-5186.
[18]	Gibot L, Chabaud S, Bouhout S,et al.Anticancer properties of chitosan on human melanoma are cell line dependent[J].Int J Biol Macromol,2015,72:370-379.
[19]	Wu P,Yu SS,Liu C,et al. Seleno-Chitosan induces apoptosis of lung cancer cell line SPC-A-1 via fas/fasL pathway[J].Bioorganic Chemistry,2020,97:103701.doi:10.1016/j.bioorg.2020.103701.Bioconjug Chem.
[20]	Jones M, Kujundzic M, John S, et al.Crab vs. mush-room: a review of crustacean and fungal chitin in wound treatment. marine drugs[J].Mar Drugs, 2020,18:69-72.
[21]	Chen X,Zhang M,Wang X,et al.Peptide-modified chitosan hydrogels promote skin wound healing by enhancing wound angio-genesis and inhibiting inflammation[J].Am J Transl Res,2017,9:2352-2362.
[22]	Kaparekar PS,Pathmanapan S,Anandasadagopan SK. Polymeric scaffold of gallic acid loaded chitosan nanoparticles infused with collagen-fibrin for wound dressing application[J].Int J Biol Macromo,2020,165:930-947.
[23]	郎咸征.评价壳聚糖抗菌凝胶治疗混合性阴道炎的临床疗效[J].中国医药指南,2018,16:111-112.
[24]	Lo WH, Deng FS, Chang CJ,et al.Synergistic antifungal activity of chitosan with fluconazole against candida albicans,candida tropicalis,and fluconazole-resistant strains[J]. Molecules,2020,25:5114-5126.
[25]	刘燕,周静,李玲.阴道镜下宫颈活检术后止血方法的运用[J].全科护理,2019,17:2095-2098.

壳聚糖药用制剂及其应用的研究进展

Research progress of application of pharmaceutical preparation chitosan

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