基础医学与临床 ›› 2022, Vol. 42 ›› Issue (9): 1449-1453.doi: 10.16352/j.issn.1001-6325.2022.09.1449

• 短篇综述 • 上一篇    下一篇

罗沙司他治疗肾性贫血的研究进展

胡宝丽1, 胡斌2*   

  1. 1. 三峡大学医学院, 湖北 宜昌 443002;
    2. 三峡大学附属仁和医院 肾内科,湖北 宜昌 443000
  • 收稿日期:2021-04-22 修回日期:2021-08-13 出版日期:2022-09-05 发布日期:2022-09-02
  • 通讯作者: hubinhxy@163.com
  • 基金资助:
    湖北省卫生健康委员会联合基金(青年人才项目)(WJ2019H561)

Research progress on roxadustat treatment for renal anemia

HU Bao-li1, HU Bin2*   

  1. 1. Medical College of China Three Gorges University, Yichang 443002;
    2. Department of Nephrology, Affiliated Renhe Hospital of China Three Gorges University,Yichang 443000,China
  • Received:2021-04-22 Revised:2021-08-13 Online:2022-09-05 Published:2022-09-02

摘要: 肾性贫血是导致慢性肾脏病(CKD)疾病进展的的独立危险因素。新型治疗肾性贫血药物罗沙司他利用机体对低氧的自然反应,激活低氧诱导信号通路,同时调控内源性促红细胞生成素(EPO)生成并改善铁代谢,有效纠正血红蛋白水平,综合调节红细胞生成。

关键词: 罗沙司他, 肾性贫血, 脯氨酰羟化酶抑制剂, 低氧诱导因子, 慢性肾脏病

Abstract: Renal anemia is an independent risk factor for progression of chronic kidney disease (CKD).Roxadustat, a novel medicine for renal anemia, utilizes the body's native response to hypoxia for activating the hypoxia-induced signaling pathway, regulating endogenous erythropoietin(EPO) production and improving iron metabolism, so effectively corrects hemoglobin level and comprehensively regulates erythropoiesis.

Key words: roxadustat, renal anemia, prolyl hydroxylase inhibitor, hypoxia-inducible factor, chronic kidney disease

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