内脂素在脓毒症相关性脏器损伤中的作用及机制研究进展

doi:10.16352/j.issn.1001-6325.2022.08.1279

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (8): 1279-1283.doi: 10.16352/j.issn.1001-6325.2022.08.1279

内脂素在脓毒症相关性脏器损伤中的作用及机制研究进展

匡重伸, 丛竹凯, 吴长毅, 杨宁, 宗亚楠, 郭向阳^*

北京大学第三医院麻醉科,北京 100191

收稿日期:2022-05-19 修回日期:2022-06-13 出版日期:2022-08-05 发布日期:2022-08-01
通讯作者: ^*puthmzk@hsc.pku.edu.cn
基金资助:
国家自然科学基金(81873726, 81971012); 北京大学临床+X青年专项(PKU2020LCXQ016)

Research progress on the role and mechanism of visfatin in sepsis-related organ injury

KUANG Zhong-shen, CONG Zhu-kai, WU Chang-yi, YANG Ning, ZONG Ya-nan, GUO Xiang-yang^*

Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China

Received:2022-05-19 Revised:2022-06-13 Online:2022-08-05 Published:2022-08-01
Contact: ^*puthmzk@hsc.pku.edu.cn

摘要/Abstract

摘要： 脓毒症(sepsis)是临床常见的急危重症,全身炎性反应(SIRS)是脓毒症发生的关键机制之一,内脂素(visfatin)作为一种重要的细胞因子,参与脓毒症引起的“炎症风暴”的发生发展。最近的临床及基础研究表明,内脂素在脓毒症的发生发展中起着重要作用,抑制内脂素的表达可改善脓毒症导致的系统炎性反应及肺、心脏、肝脏等重要脏器的损伤。结合目前的临床及基础研究结果分析,内脂素有望成为脓毒症疾病严重程度的评价指标以及潜在的临床干预靶点。

关键词: 内脂素, 脓毒症, 多器官功能障碍综合征

Abstract: Sepsis is a common acute and critical disease in clinic. Systemic inflammatory response (SIRS) is one of the key mechanisms for the occurrence of sepsis. Visfatin, as an important cytokine, is involved in the occurrence and development of “cytokines storm” caused by sepsis. Recent clinical and basic research have shown that visfatin plays an important role in the occurrence and development of sepsis, and inhibition of visfatin expression can improve the systemic inflammatory response and the damage of lung, heart, liver and other important organs caused by sepsis. Based on the analysis of current clinical and basic research results, visfatin are expected to become an indicator of the severity of sepsis and a potential target for clinical intervention.

Key words: visfatin, sepsis, MODS

中图分类号:

R363

匡重伸, 丛竹凯, 吴长毅, 杨宁, 宗亚楠, 郭向阳. 内脂素在脓毒症相关性脏器损伤中的作用及机制研究进展[J]. 基础医学与临床, 2022, 42(8): 1279-1283.

KUANG Zhong-shen, CONG Zhu-kai, WU Chang-yi, YANG Ning, ZONG Ya-nan, GUO Xiang-yang. Research progress on the role and mechanism of visfatin in sepsis-related organ injury[J]. Basic & Clinical Medicine, 2022, 42(8): 1279-1283.

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内脂素在脓毒症相关性脏器损伤中的作用及机制研究进展

Research progress on the role and mechanism of visfatin in sepsis-related organ injury

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