目的 系统评价姜黄素(curcumin)治疗2型糖尿病(type Ⅱ diabetes mellitus,T2DM)的有效性。方法 检索The Cochrane Library、PubMed、Embase、中国知网、万方数据库、中国生物医学文献数据库(CMB),纳入评价姜黄素治疗T2DM随机对照试验(randomized controlled trial,RCT),检索时限从建库起至2020年12月。按纳入与排除标准筛选文献、提取资料并评估纳入研究的方法学质量后,采用Revman 5.4软件进行Meta分析。结果 共8项RCTs纳入分析,包括531例患者,治疗组267例,对照组264例。治疗组患者在基础治疗同时加用姜黄素,对照组患者在基础治疗同时只加用安慰剂(Placebo)。结局指标包括甘油三酯(triglycerides,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、体重指数(body mass index,BMI)、空腹血糖(fasting blood glucose,FBG)和糖化血红蛋白(glycosylated hemoglobin,HbA1c)。Meta分析结果显示,两组在TG(MD=-13.99,95%CI:-26.91～-1.07,P=0.03＜0.05)、TC(MD=-11.30,95%CI:-20.69～-1.91,P=0.02＜0.05)、HDL-C(MD＝2.92,95%CI:1.65～4.19,P＜0.01)、LDL-C(MD=-11.19,95%CI:-19.54～-2.84,P＜0.01)、BMI(MD=-1.75,95%CI:-2.23～-1.27,P＜0.01)、FBG(MD=-14.49,95%CI:-21.20～-7.79,P＜0.01)和HbA1c(MD=-0.85,95%CI:-1.16～-0.54,P＜0.01),均有统计学意义。结论 姜黄素能有效改善2型糖尿病患者的多项生化指标,降低心脑血管疾病的风险。
Abstract
OBJECTIVE To evaluate systematically the efficacy of curcumin in the treatment of type Ⅱ diabetes mellitus(T2DM). METHODS The Cochrane Library, PubMed, Embase, CNKI, Wanfang Data, and The China Biomedical Data Database(CMB)were retrieved until December 2020.The randomized controlled trials(RCTs)evaluating curcumin for T2DM were included.After selecting the literature according to the inclusion and exclusion criteria, extracting the data and evaluating the methodological quality of the included studies, the Revman 5.4 software was used for Meta analysis. RESULTS A total of 8 RCTs were included in the analysis, including 531 patients with 267 in the experimental group and 264 in the control group. In addition to the basic treatment, patients in the treatment group were given curcumin, while patients in the control group were given a placebo.Outcome measures included triglycerides(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), body mass index(BMI), fasting blood glucose(FBG) and glycosylated hemoglobin(HbA1c). RESULTS showed that there were significant differences in TG(MD=-13.99, 95%CI:-26.91--1.07, P=0.03＜0.05), TC(MD=-11.30, 95%CI:-20.69--1.91, P=0.02＜0.05), HDL-C(MD＝2.92, 95%CI: 1.65-4.19, P＜0.01), LDL-C(MD=-11.19, 95%CI:-19.54--2.84, P＜0.01), BMI(MD=-1.75, 95%CI:-2.23--1.27, P＜0.01), FBG(MD=-14.49, 95%CI:-21.20--7.79, P＜0.01) and HbA1c(MD=-0.85, 95%CI:-1.16--0.54, P＜0.01). CONCLUSION Curcumin can effectively improve multiple biochemical indexes in patients with type 2 diabetes and reduce the risk of cardiovascular and cerebrovascular diseases.
关键词
姜黄素 /
2型糖尿病 /
Meta分析 /
随机对照试验
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Key words
curcumin /
type Ⅱ diabetes mellitus /
Meta-analysis /
randomized controlled trial
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参考文献
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