摘要
目的综述挤出-滚圆法的不同因素对于微丸的形成及其释药行为的影响。方法查阅国内外相关文献,进行整理、归纳和总结,以微丸的性质和药物的释放为指标,考察影响挤出-滚圆法的各因素。结果与结论制剂的处方及工艺对微丸均有影响,通过对挤出滚圆中处方和参数的优化,可获得满意的成丸效果及释药行为,以达到制剂目的。
关键词
微丸 /
挤出-滚圆法 /
影响因素 /
药物释放
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刘耀;刘松青.
挤出-滚圆法制备微丸的研究进展[J]. 中国药学杂志, 2008, 43(06): 401-405
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