乌灵菌粉的镇静作用及其机理研究

马志章;左萍萍;陈宛如;唐利军;沈琦;孙晓华;沈云

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (06) : 374-377.

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (06) : 374-377.
药理

乌灵菌粉的镇静作用及其机理研究

  • 马志章;左萍萍;陈宛如;唐利军;沈琦;孙晓华;沈云
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Studies on the sedative and sleeping effects of Wuling mycelia and its pharmacological mechanism

  • Ma Zhizhang
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文章历史 +

摘要

目的:研究真菌中药乌灵菌粉对小鼠的镇静安眼作用及其机制?方法:以常规的药理试验方法检测本药在戊巴比妥钠协同下对小鼠睡眠的影响;以同位素掺入法研究作用机理?结果:乌灵菌粉在戊巴比妥钠协同下有明显的促睡眠作用,并使自主活动减少?同时服药小鼠脑内谷氨酸(Glu)和γ-氨基丁酸(GABA)的含量及GABA受体的结合活性均高于对照,药物还能提高谷氨酸脱羧酶(GAD)的活性?结论:乌灵菌粉可能是通过促使Glu,GABA进入脑内,提高GAD活性及激活GABA受体而实现其镇静作用?

Abstract

OBJECTIVE: To reveal the sedative and sleeping effcets of Wuling mycelia (a Chinese medicine) and the mechanism involved.METHODS: By using the routine pharmacological methods,the synergistically sedative and sleeping effects of Wuling mycelia and nembutal sodium were detected in mice,while the mechanism involved was investigated by isotope incorporation assay. RESULTS: Powdered Wuling mycelia in combination with nembutal sodium could promote sleep and decrease autonomic locomotions of mice.After administration of Wuling mycelia,the contents of glutamic acid (Glu) and γ-aminobutyric acid (GABA) and the binding affinity of GABA receptors in the brain were found to be augmented as compared with those of controls.Further,the activity of glutamate decarboxylase (GAD) could also be elevated. CONCLUSION: The data suggested that Wuling mycelia possesses the ability to facilitate the entry of Glu and GABA into the brain,to activate the receptors of GABA and thus to exert its sedative and sleep-promoting properties.

关键词

乌灵菌粉 / 镇静安眠 / 谷氨酸 / γ-氨基丁酸 / 谷氨酸脱羧酶

Key words

Wuling mycelia / sedative and sleeping / Glu / GABA / GADes.

引用本文

导出引用
马志章;左萍萍;陈宛如;唐利军;沈琦;孙晓华;沈云. 乌灵菌粉的镇静作用及其机理研究[J]. 中国药学杂志, 1999, 34(06): 374-377
M Zhizhng. Studies on the sedative and sleeping effects of Wuling mycelia and its pharmacological mechanism[J]. Chinese Pharmaceutical Journal, 1999, 34(06): 374-377

参考文献

1 四川省中医中药研究所主编.四川中药志.第2册.成都:四川人民出版社,1960:1434. 2 徐叔云,卞如濂,陈修主编.药理实验方法学.第2版,北京:人民卫生出版社,1991,657~658. 3 夏宗勤主编.实验核医学与核药学.上海:同济大学出版社,1989,255. 4 Kimura H,Kuriyama K.A new microassay method for L-glutamic acid decarboxylase(GAD)activity.Jpn J Pharmacol,1975,25:189. 5 徐叔云主编.中药临床药理.北京:华夏出版社,1997,1217~1218.

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