Abstract: Objective To investigate gene expression patterns of atherosclerosis (As) induced by intermittent hypoxia and hyperlipemia. Methods Isolation total mRNA of liver tissue from atherosclerosis rabbit model in hyperlipemia group and hyperlipemia with intermittent hypoxia group. Suppression subtractive hybridization was adopted to construct cDNA lib, and to identify differential expression by opposite Northern blot, after insertion element was sequenced blast analysis by quantitate RT-PCR. The expression of histone deacetylase 7 was obviously difference in two groups. Results MYL6 and HDAC7 were screened in cDNA lib. Conclusion The process of atherosclerosis induced by intermittent hypoxia is correlated to many genes. HDAC7 is a gene play new important role in AS.