Abstract: Objection To determine the predictive value of wheat germ agglutinin receptor (WGAR) on human spermatozoa surface, the frequency of abnormitic sperm morphology and human spermatozoa acrosin activities to fertilization rate of IVF-ET.Methods Spermatozoa and oocytes were obtained from both normospermic men and women patients with oviduct obstruction,They came to our center for IVF procedure. Statistics of the quantitation of WGAR on spermatozoa, the frequency of abnormitic sperm morphology, human spermatozoa acrosin activities and the fertilization rate of IVF-ET were made. Result Two groups based on the fertilization rate less than 65% (n=64)and over 65%(n=194) were divided, there was a significant difference about their amount of the WGAR(P<0.01);there was not significantly different about the frequency of abnormitic sperm morphology and human spermatozoa acrosin activities(P>0.01;P<0.05). Conclution The fertilization rate of IVF-ET was affected by the amount of WGAR on spermatozoa, the frequency of abnormitic sperm morphology and human spermatozoa acrosin activities,while the amunt of WGAR on spermatozoa might be more useful to predict fertilization rates in vitro