Abstract: Ojective To study the pathological changes of testis tissue in male SARS patients. Methods Tissue specimens were studied by HE staining、TUNEL and immunohistochemistry(IHC). Results All testes from the SARS patients demonstrated that widespead germ cells destruction,few or no spermatozoon in the seminiferous epithelium and the lumen, thickened basement membrane、 peritubular fibrosis、 vascular congestion and leukocytes infiltration obviously. The apoptotic seminiferous cells increased significantly(P<0.05).The numbers of CD3+ T lymphocyte and CD68+ macrophage increased significantly in the interstitial tissue compared with the control group(P<0.05), and both cells were observed infiltration in the tubules. Conclusions Our study implied that SARS caused orchitis.