Organ-on-a-chip: a more promising in vitro model

doi:10.16352/j.issn.1001-6325.2024.09.1202

Abstract

Abstract: Traditional in vitro models have inevitable limitations and there are significant differences in assessing drug efficacy and side effects as compared to human trials. Organ-on-a-chip technology simulates human organs in a physiological environment and functional chip with a high fidelity physiological or pathophysiological level, offering great innovative prospects for drug development. This paper mainly introduces the research progress and application of organ chip from the perspective of various systems in vivo. At the same time, the limitations of the current development process of organ chip and the future development direction are proposed.

Key words: organ-on-a-chip, organoid, disease model

CLC Number:

R318.19

YANG Zhenli, XIA Yujia, LIU Yuqin. Organ-on-a-chip: a more promising in vitro model[J]. Basic & Clinical Medicine, 2024, 44(9): 1202-1207.

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