Basic & Clinical Medicine ›› 2024, Vol. 44 ›› Issue (3): 389-392.doi: 10.16352/j.issn.1001-6325.2024.03.0389

• Mini Reviews • Previous Articles     Next Articles

Research progress on P2X7 receptor in cancer pain

ZHANG Zhongwen1, ZHAO Rui2, ZHANG Haolong3, YANG Yuting4, BAI Jinxia4, ZHANG Haoling3* WANG Wei*   

  1. 1. School of Public Health; 2. Clinical College of Chinese Medicine; 4. College of Acupuncture-Moxibustion and Tuing, Gansu University of Chinese Medicine, Lanzhou 730000, China;
    3. Advanced Medical and Dental Institute, University Sains Malaysia,Penang 13200, Malaysia
  • Received:2023-06-07 Revised:2023-12-01 Online:2024-03-05 Published:2024-02-22
  • Contact: *:wangwei@gszy.edu.cn;zhanghaolingedu@163.com

Abstract: The activation of the P2X7 receptor as an ATP-gated ion channel, triggers the release of pro-inflammatory cytokines in tumor carring individuals and stimulate excitation of injury-causing neurons, thereby exacerbating the transmission of pain. In preclinical cancer pain models, it has the potential to serve as a new therapeutic target for cancer pain management.

Key words: P2X7 receptor, cancer pain, glial cell, P2X7 antagonist

CLC Number: